Formative I

Question 1

Main Antibody induction difference between Intramuscular and Oral vaccines

Answer 1

intramuscular induces IgG, mucosal induces IgA

Question 2

What are the soluble pattern recognition molecules present in healthy individual’s serum?

Answer 2

Complement has many soluble ones

• Mannose Binding Lectin is in high concentration in the plasma
• Lysozyme

Question 3

What chemokine produces C reactive protein?

Answer 3

IL-6

Question 4

steps in the maturation of lymphocytes

Answer 4

1. proliferation
2. pre-B/T antigen receptor expression
3. Proliferation
4. Antigen receptor expression
5. Positive and negative selection
6. • goes to mature T/B cell
     6b. - goes to apoptosis due to strong self antigen recognition
     6c. failure of positive selection because of no self antigen recognition

Question 5

Steps in recombination and expression of Ig genes

Answer 5

Germline DNA undergoes Somatic recombination (D-J joining) in C cell clones

Somatic Recombination (V-DJ joining) in two B cell clones

Transcription

RNA processing and splicing

Translation

IgM formation

Question 6

How is junctional diversity involved in VDJ recombination?

Answer 6

TdT involved here