Poiseuilles Law
Q = 3.14 x Pr^4/8nL Flow is directly relate to pressure Length is directly relate to pressure Viscosity is directly relate to pressure Pressure is inversely proportional to the radius to the fourth power
DO2 (Total Oxygen Delivery)
CO (Cardiac Output) x (CaO2 x 10)
CO= QT (Same thing)
Normal CO = 5 Lpm
A-aO2 (Alveolar-arterial oxygen gradient)
PAO2 - PaO2
Normal: 5-10 mmHg
Gradient can increase with higher FiO2, ex: 100% FiO2, A-a gradient can be 100-150
Elevated A-aO2 indicates hypoxemia is due to V/Q mismatch, Shunt or impaired diffusion
Normal: Indicates the hypoxemia is due to hypoventilation (Elevated PaCO2) or low barometric pressure.
DO2 Decrease
Low blood oxygenation Low PaO2 Low SaO2 Low Hb concentration Low Cardiac Output
DO2 Increase
Increased PaO2
Increased SaO2
Increased Hb concentration
Increased Cardiac Output