GABA A Flashcards by Liam Colclough

Q

How is GABA made

A

Glutamate altered by GAD (glutamic acid decarboxylase)

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Q

GABA transporter on nerve terminals

A

GAT1

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Q

GABA transporter on astrocytes

A

GAT3

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Q

GABA transport blocker

A

Tiagabine

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Q

GABA destoyed by

A

GABA transaminase

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Q

GABA-Tranaminase blokcer

A

Vigabatrin

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Q

GABA A structure

A

Pentamer, subunits a, b, y, d, e

Each subunit has 4TM

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Q

What ions do gaba A let through

A

Cl-

HCO3-

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Q

Most common arrangement of subunits in receptor

A

a, b, a, b, y/d/e

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Q

Which subunits do GABA bind in between

A

a and b. 2 GABA needed

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Q

Where do benzos bind

A

BEtween a and y

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Q

How much gaba is release per synapse

A

1-3 mmol

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