Gastritis

Question 1

Description: What is gastritis?

Answer 1

Inflammation of the gastric mucosa (can be chronic or acute)

Question 2

Aetiology: What are the causes of gastritis (3)

Answer 2

• Autoimmune (parietal cells)
• Bacteria (H.pylori) = MOST COMMON
• Chemical (NSAIDs/Bile/Alcohol)

Question 3

Pathology: Describe the pathology of autoimmune gastritis

Answer 3

Autoantibodies destroy/to

• Parietal cells (which leads to decreased acid secretion)
• Intrinsic factor (which leads to vitamin B12 deficiency)

Question 4

Symptoms: What are the symptoms of gastritis? (not in the lecture)

Answer 4

• Epigastric pain

- Vomiting

Question 5

THE SIGNS WERE NOT IN THE LECTURE

Answer 5

THE SIGNS WERE NOT IN THE LECTURE

Question 6

Investigations: What investigations do we do for gastritis:

(a) Non-invasive tests
(b) Invasive tests

Answer 6

(a) Non-invasive:
- Stool antigen test (ELISA) – you need to be off protein pump inhibitors for 2 weeks
- 13C/14C urea breath test
- Serology (IgG against H.pylori)
(b) Invasive:

Requires endoscopy:

• Histology
• Culture
• Rapid slide urease test (CLO)

Question 7

THE TREATMENT WAS NOT IN THE LECTURE but

answer it anyway

Answer 7

• H.pylori eradication – triple therapy

Question 8

THE COMPLICATIONS WERE NOT IN THE LECTURE

Answer 8

THE COMPLICATIONS WERE NOT IN THE LECTURE

Question 9

Extra: State 4 characteristics about H.pylori

Answer 9

• Gram negative (bacillus)
• Flagellated
• Spiral-shaped
• Microaerophilic

Question 10

Extra: Where does H.pylori colonise and reside?

Answer 10

Colonises gastic type mucosa. Does not penetrate the epithelial layer