GB

Question 1

PASMCs

Answer 1

Pulmonary artery smooth muscle cells

Question 2

PDGFR

Answer 2

plateled-derived growth factor receptor

Question 3

CSF I R

Answer 3

colony stimulating factor I receptor

Question 4

c-KIT

Answer 4

stem cell factor receptor

Question 5

Seralutinib

Answer 5

Novel, potent, clinical stage inhibitor of
PDGFR alfa/beta
CSF I R
and c-KIT

Question 6

TORREY, a phase 2 study
primary endpoint

Answer 6

the change from baseline to Week 24 in PVR by RHC

Question 7

TORREY, a phase 2 study
the secondary endpoint

Answer 7

the change in distance from baseline to Week 24 achieved in the 6MWT

Question 8

TORREY, a phase 2 study
CT sub-study

Answer 8

will examine the effect of seralutinib on pulmonary vascular remodeling

Question 9

TORREY, a phase 2 study
a separate heart rate monitoring sub-study

Answer 9

will examine the effect of seralutinib on cardiac effort during the 6MWT