GBS

Question 1

Early onset GBS is classified as occurring:

Answer 1

Between 0-6 days of life

Question 2

Late onset GBS is classified as:

Answer 2

Between 7-89 days

Question 3

How many babies with early or late GBS meningitis have long term neurologic sequelae?

Answer 3

50%

Question 4

What type of bacteria is Group B Strep?

Answer 4

gram-positive, aerobic diplococci

Question 5

What type of GBS usually infects infants?

Answer 5

Type III is the predominant cause of early-onset meningitis and the majority of late-onset infections in infants

Question 6

Where does GBS come from?

Answer 6

Group B streptococci are common inhabitants of the human gastrointestinal and genitourinary tracts

Question 7

What is the colonization rate in pregnant women for GBS?

Answer 7

The colonization rate in pregnant women ranges from 15% to 35%. Colonization during pregnancy can be constant or intermittent

Question 8

Do intrapartum antibiotics affect early-onset or late-onset GBS disease, or both?

Answer 8

ONLY early onset. The use of intrapartum chemoprophylaxis has had no measurable impact on late-onset GBS disease.

Question 9

What are risk factors for early-onset GBS disease? (name 7 items)

Answer 9

• Preterm infants (less than 37 weeks’ gestation),
• ROM x 18 hours or more,
• Infants born to women with high genital GBS inoculum
• intrapartum fever (temperature 38°C [100.4°F] or greater)
• chorioamnionitis
• GBS bacteriuria during the current pregnancy
• previous infant with invasive GBS disease