Gene Expression

Question 1

what is the key control point for regulating protein levels

Answer 1

regulation of transcription

Question 2

where do transcription factors bind to DNA

Answer 2

bind to the OUTSIDE of the DNA, in the MAJOR groove; recognition of any given base pair can be recognized in the major groove (A-T vs. T-A; G-C vs. C-G)

Question 3

DNA-binding motifs

Answer 3

many TFs can have similar binding motifs (helix-turn-helix motif, zinc fingers, etc)

Question 4

how can mutations in gene regulation cause disease

Answer 4

mutations in transcription factors, enhancer/silencer sites, etc, can cause disease