General

Question 1

2 major divisions

Answer 1

**noninfectious (primary/autoimmune)

infectious

Question 2

Infectious causes of vasculitis

Answer 2

1. fungi (aspergillus)
2. bacteria (pseudomonas)
3. virus (cytomegalovirus)

Question 3

infectious vasculitits may be called…

Answer 3

mycotic aneurysm

regardless of cause of infection

Question 4

Causes of Primary vasculitis

Answer 4

1. cell-mediated response (T-cells, macrophages, cytokines) to vascular antigens (i.e. elastic lamina) when dendritic cells go haywire
2. immune-complex deposition–> inflammation mediated by complement, neutrophils, lysosomal enzymes, free radicals
3. antibody-mediated attack
4. Unknown

Question 5

Signs and symptoms

Answer 5

fever
…..

**“Palpable purpura”
…..

livedo reticularis

MANY more nonspecific signs and some specific signs

Question 6

livedo reticularis

Answer 6

network-pattern purplish discoloration of skin due to dilatation of blood vessels

Question 7

What can cause a FUO (fever of unknown origin)?

Answer 7

Vasculitis

Infective Endocarditits

Question 8

What are taken into consideration for making diagnosis of vasculitis besides clinical presentation?

Answer 8

distribution of organ involvement
histopathological features (biopsy)

Question 9

Most common types of Vasculitis

Answer 9

Just vasculitis
Hypersensitivity angiitis
Temporal arteritis

Question 10

Less common types of Vasculitis

Answer 10

infectious
Wegener's granulomatosis
Henoch-Schonlein purpura
Microscopic polyarteritis
polyarteritis nodosa