Gentamicin

Question 1

class of gentamicin

Answer 1

aminoglycosides

Question 2

how does gentamicin block protein synthesis

Answer 2

bacteriocidal/bacteriostatic. irreversible binding to 30s ribosomal subunit –> misread mRNA

Question 3

resistant aerobic gram -ve bac targeted by gentamicin

Answer 3

• enterobacter
• serratia
• klebsiella

Question 4

indications for gentamicin

Answer 4

• septicaemia
• meningitis
• nosocomial RTI
• complicated UTI
• intra-abdominal infections

Question 5

contraindications gentamicin

Answer 5

• preggo

- myasthenia gravis

Question 6

SEs gentamicin

Answer 6

• nephrotoxicity
• ototoxicity (irreversible)
• abx-colitis

Question 7

gentamicin is mostly excreted via

Answer 7

urine