Geral

Question 1

Miller-Fisher Syndrome: features

Answer 1

ophthalmoplegia + ataxia + areflexia

Question 2

Miller-Fisher Syndrome: antibody

Answer 2

anti-GQ1b

Question 3

Miller-Fisher Syndrome: treatment

Answer 3

IV Ig

Question 4

anorexia nervosa > non-thyroidal illness syndrome

Answer 4

low T3 - no treatment required

Question 5

Wilson’s disease: 4 clinical manifestations

Answer 5

neurological features (bradykinesia, rigidity, tremor) + hepatic dysfunction + psychiatric manifestations + Kayser-Fleischer rings

Question 6

Wilson’s disease - treatment

Answer 6

penilcillamine

Question 7

pulmonary arterial hypertension - gold standard diagnosis

Answer 7

right heart catheterization

Question 8

pulmonary arterial hypertension - treatment

Answer 8

endothelin receptors antagonist (bosentan)

Question 9

hypertrophic pulmonary osteoarthropathy - 3 features

Answer 9

digital clubbing + periostitis + painful arthropathy

Question 10

confusion + ataxia + oculomotor dysfunction

Answer 10

Wernicke’s encephalopathy

Question 11

Wernicke’s encephalopathy - acute management

Answer 11

IV thiamine

Question 12

MEN1

Answer 12

anterior pituitary gland + pancreas + parathyroid

Question 13

anterior pituitary gland + pancreas + parathyroid

Answer 13

MEN1

Question 14

MEN2A

Answer 14

medullary thyroid carcinoma + pheochromocytoma + parathyroid

Question 15

medullary thyroid carcinoma + pheochromocytoma + parathyroid

Answer 15

MEN2A

Question 16

MEN2B

Answer 16

medullary thyroid carcinoma + pheochromocytoma + mucosal neuromas + marfanoid habitus

Question 17

medullary thyroid carcinoma + pheochromocytoma + mucosal neuromas + marfanoid habitus

Answer 17

MEN2B

Question 18

acute hepatic encephalopathy - initial management

Answer 18

lactulose

Question 19

first-line management of HCM

Answer 19

beta-blocker

Question 20

café-au-lait spot + neurofibromas + axillary/inguinal freckles + Lisch nodules

Answer 20

neurofibromatosis type 1

Question 21

bilateral vestibular schwannoma - think of…

Answer 21

neurofibromatosis type 2

Question 22

blue sclera + recurrent fractures + poor dentition + osteoporosis + hearing loss

Answer 22

osteogenesis imperfecta

Question 23

seizures + hypopigmented spots + facial angiofibromas

Answer 23

tuberous sclerosis

Question 24

tuberous sclerosis

Answer 24

seizures + hypopigmented spots + facial angiofibromas

Question 25

acute respiratory distress syndrome is a recognized complication of...

Answer 25

acute pancreatitis

Question 26

most common mechanism of malignancy-associated hypercalcaemia / PTH is...

Answer 26

PTHrP-mediated hypercalcaemia / suppressed

Question 27

hypotension resistant to fluid resuscitation + ↓Na + ↑K + ↓glucose + fatigue + abdominal pain / management

Answer 27

acute adrenal crisis / IV hydrocortisone

Question 28

permissive hypertension in ischemic stroke

Answer 28

up to 220/120mmHg

Question 29

if thrombolysis planned, lower BP to...

Answer 29

< 185/110mmHg

Question 30

autosomal dominant polycystic kidney disease - initial investigation / increased risk of... + screening modality of choice

Answer 30

renal ultrasound / intracranial aneurysms + MRI angiography

Question 31

supplemental oxygen in ACS

Answer 31

only if SpO2 < 90%

Question 32

bilateral symmetrical progressive ascending limb weakness, sensory loss and areflexia on the background of a recent infection

Answer 32

Guillain-Barré syndrome

Question 33

bilateral hilar lymphadenopathy + arthritis + erythema nodosum

Answer 33

acute sarcoidosis (Lofgren syndrome)

Question 34

sarcoidosis > hyper...

Answer 34

hypercalcaemia

Question 35

↑T3 and T4 + absence of goitre + ↓thyroglobulin + ↓radioactive iodine uptake

Answer 35

factitious thyrotoxicosis

Question 36

factitious thyrotoxicosis - excellent response to...

Answer 36

cholestyramine treatment

Question 37

investigation for suspected IgE-mediated food allergy

Answer 37

skin prick testing

Question 38

alcoholic hepatitis - liver enzymes ratio

Answer 38

2 AST: 1 ALT

Question 39

signs of familial hypercholesterolemia

Answer 39

corneal archus and tendon xanthomas