Glomerular Filter Rate

Question 1

GFR defintion

Answer 1

volume filtered/min/kg

Question 2

explain glomerular filtrate

Answer 2

the filtrate that is secreted from the Glomerularus
the composition is similar to plasma but without any significant amount of proteins
contains things that need to be reabsorbed such as glucose and amino acids

composition

• water
• electrolytes - Na+, K+, Ca2+, Cl-, phosphates and bicarbonate
• low molecular weight substances

Question 3

Explain the three things that affects GFR

Answer 3

1. Blood pressure/ hydrostatic pressure
2. Oncotic pressure/colloid pressure (osmotic forces)
3. Filtration coefficient (capillary wall permeability + S.A. effective filtration)

note- often total GFR is reduced due to the loss of the fx of many of nephrons, which others try to compensate