4 clinicopathologic entities encompassed by GTD
hydatidiform mole (complete and partial), invasive mole, choriocarcinoma, placental site trophoblastic tumors
entities encompassed by GTN
invasive mole, choriocarcinoma, placental site trophoblastic tumors
overall cure rate with GTN
90%
GTD incidence
1:1000 pregnancies
risk factors for GTD
extremes of age, history of prior molar pregnancy, low beta carotene and animal fat intake
risk of repeat molar pregnancy after a mole
1% (risk increases to 15-28% with a history of 2+ previous molar pregnancies)
choriocarcinoma risk factors
previous complete mole, ethnicity, advanced maternal age