GU Flashcards

(683 cards)

1
Q

Oligospermia

A

Low sperm count

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2
Q

Azospermia

A

No sperm count

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3
Q

Asthenozoospermia

A

Poor sperm motility

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4
Q

Oligoasethenozoospermia

A

Poor sperm motility and low sperm count

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5
Q

What dayof menstrual cycle does bleeding start

A

Day 1

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6
Q

Whcih day of menstrual cycle does basal body temp start to rise

A

Day 14

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7
Q

Which two hormones are elevated around menstural cycle day 14

A

LH and estrogen

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8
Q

Wht is predominant hormones during luteal phase

A

Progesterone

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9
Q

How long does normal menstrual cycle last

A

24-38 days
Bleeds for 2-7 days

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10
Q

How much blood loss in menstrual cycle

A

5-80mL

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11
Q

Menopause definitino

A

one year without period
Elevated FSH
Low estradiol

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12
Q

Average age of menopause

A

51.5

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13
Q

Nulligravida

A

Never preg

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14
Q

Primigravidia

A

First preg

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15
Q

Secundigravida

A

Second preg

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16
Q

Multigravida

A

Pregnant more than once

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17
Q

Grand multigravida

A

Preg more than 5 times

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18
Q

Ladin’s sign

A

Uterus softening after 6 weeks

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19
Q

Hegar’s sign

A

Uterine istmus softening after 6-8 weeks

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20
Q

Goodell’s sign

A

Cervical softening 4-5 weeks

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21
Q

Chadwick’s sign

A

Blue cervix 8-12 weeks

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22
Q

Miscarriage

A

Preg lost up to 20 weeks

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23
Q

Second trimester preg loss

A

between 13-20 weeks

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24
Q

Stillbirth/fetal death

A

PReg loss occurs >20 weeks or weight >350 grams

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25
Blighted ovum
Nonviable preg with gestational sac with no yolk sac or embryo
26
First trimester
1-13 weeks
27
Second trimester
14-27 weeks
28
Third trimester
>28 weeks
29
Gravida
How many conceptions/pregnancies pt has had Includes miscarriages, preg terminations, ectopic pregnancies
30
Para
Pregnancy outcome Number of time pt has birthed a chid Includes stillbirths
31
Naegele's rule
Estimateed day of delivery First day of last menstrual period plus 9 months and 7 days
32
Prenatal vitamin
folic acid
33
Glans
Head of penis
34
Meatus
Opening of tip of glans where urine and semen exit
35
Prepuce
Foreskin
36
Corpus cavernosa
Two columns of spongy tissue that runs along interior shaft of penis Stiffens when filled with blood
37
Corpus spongiosum
Column of tissue that prevents urethra from closing during erection
38
Testes
Store sperm
39
Seminiferous tubules
Coiled tues that make up most of testis that are responsible for spermatogenesis
40
Sertoli cells
Part of epithelium cells that line seminiferous tubules that aid in production of hormones that produce sperm
41
Leydig cells
Tissue next to seminiferous tubules that produce male hormones like testosterone and other androgens
42
Vas deferens
AKA Ductus deferens or sperm duct Runs from epididymitis and connects to urethra through ejaculatory duct
43
Rete testis
Sperm cells travel toward epidymis in this
44
Efferent ducts
Series of tubes that join rete testis to epidiymis that absorb most of fluid to move sperm cels
45
Epididymis
Stores sperm until mature
46
Tunica vasculosa
First thin layer of blood vessels around testes
47
Tunica albuginea
Thick protective layer to protect testes
48
Tunica viginalis
Made up of three layers to further protect testes
49
Layers of tissue that surround testes
TUnic avasculosa TUnica albuginea Tunica vaginalis
50
Varicocele presentation
Usually on left side (if on right suspect malignancy) DIlation of pampiniform plexus of spermatic veins Scrotal fullness that changes in size depending on position Bag of worms consistency Maybe dull ache
51
Most common surgiclaly corrected cause of male infertility
Varicocele
52
Varicocele management
Observation Surgery in pt with pain, infertility, delayed testicular growth
53
What does sudden onset left-sided vacricocele in older man indicate
Renal cell carcinoma
54
What does right-sided varicocele indidcate
Retroperitoneal or abd malignancy
55
Varicocele initial imaging
Testicular US shownig dilation of pampiniform plexus>2mm
56
Hydrocele
Collection of serous fluid between parietal and visceral layers of tunica vaginalis surrounding testis and spermaticord
57
Hydrocele diagnostic imaging
Testicular US to rule out tumor or orchitis Can also look at transilumniation
58
Hydrocele presentation
Unilateral r bilateral scrotal fullness, uniform consistency
59
Hydrocele causes
Idiopathic MC INflammatory conditions
60
Types of hydroceles
Communicating (abd fluid enters scrotum through patent processus vaginalis that failed to close) Non communicating (fluid from mesothelial lining of tunica vaginalis with no connection to peritoneum
61
Hydroceles treatment
Observation Surgery if older pt with communicating or if persists beyond year of age in infants
62
Spermatocele
AKA epididymal cyst > 2cm
63
Spermatocele presentation
Localized fullness or firmness in head of epididymis Typically painless Round, soft mass, separate from testical Freely movable masss above testicle that transilluminates
64
Spermatocele diagnostic imaging
Testicular ultrasound
65
Spermatocele treatment
Observation Surgery if bothersome or painful
66
Epididymitis
Swelling from infection or reflux or urine ususally caused by bacterial infection
67
Epididymits cause
Males 14-35: chalmydia, gonorrhoeae Males>35: E. coli Prepubertal males: E. coli
68
Epididymitis presentation
Gradual onset testicular swelling Unilateral with fever, chills, dysuria, freq, urgency, urethritis Scrotal swelling and tenderness Positive prehn sign (relief of pain with scrotal elevation Positive (normal) cremateric reflex (elevation of testicles after stroking inner thigh
69
Epididymitis diagnostic imgaging
Testicular ultrasound showing enlarged epididymis and increased testicular bloodflow
70
Epididymitis labs
UA with pyuria, positive leuocyte esterase Nucleic acid amplification testing for gonorrhea and chlamydia
71
Epididymitis Treatment
Scrotal elevatoin NSIDs COld compresses Abx (doxycycline and cephtriaxone) (ceftriaxone and fluoroquinolone for men who do anal)
72
Orchitis cause
mumps virus (paramyxovirus)
73
orchitis presentation
Scrotal pain Swelling Tenderness
74
Orchitis treatment
NSAIDs Bedrest Scrotal support Warm/cool packs
75
Testicular cancer risk factors
Cryptochordism White Klinefelter's syndrome Hypospadias
76
Most common type of testicular cancer
Germinal cell tumor
77
Two types of germ cell tumors
Seminomas Nonseminomas
78
Two types of non germ cell tumors
Leydig Sertoli
79
Noneminomas types
Embryonal cell carcinoma (yook sac in young boys) Choriocarcinoma (worse prognosis) Mixed tumors
80
Seminomas charcteristics
Simple Sensitive to radiation Slower growning Step wise spread
81
Testicular cancer presentation
usually painless hard testicular mass maybe dull pain Testicular swelling or heaviness Bac pain Breast sensitivity
82
Testicular cancer inital imaging
Testicular US shwong hypoechoic mass in seminoma or cystic nonhomogenous mass in nonseminoma
83
Testicle cancer treatment
Radical orchiectomy Bleomycin, etoposide, cisplatin for persistant tumor markers after orchiectomy
84
Infertility definition
Inability to achieve child after one year of intercourse without contraceptive use
85
What to do on exam for male infertility
Assess features of hypogonadism Check testicular size and consistancy
86
Male infertility treatmetn
Educatio on intercourse timing with ovulatory cycle Lifestyle habits Fix underlying problem
87
Most common causes of urethritis
Gonococcal Chlamydia
88
Urethritis presentation
Dysuria Discharge (usually in morning) (usually in gonocooccal) Penile pruritis
89
Urethritis diagnostic tsting
NAAT
90
Urethritis treatment
Gonococcal - Ceftriaxone IM Nongonooccal - Doxycycline or azithromcyin PO x 7 days In BOTH no sex for 7 days from initiation of terapy
91
Urethral stricture causes
STI or UTI Trauma Instrumentation of urethra Idiopathic INflammatory conditions Hypospadias
92
Urethral stricture presentation
Weak urine stream Incomplete bladder emptying Recurrent UTIs Urinary spraying Diysurea
93
Urethral stricture diagnostic tests
US to meadsure urine in bladder after voiding Uroflowmetry Cystourethroscopy Retrograde urethrogram looking for trauma with dye Voiding cystourethrogram to see if urine flows back from bladder to kidney Ultrasound ureofraphy cath placed in urethral meatus ad balloon expanded to form seal and contrast ran into urethra
94
Urethral stricture treatment
Endoscopic dilation Intermittent catheter dilation Urinary diversion procedures Surgical reconstruction
95
Urethral injuries causes
Blunt trauma most common Physical or sexual assault
96
Urethral injury clinical manifestations
Gross hematuria Diff urinating Urinary retention (distended bladder) Lower abd pain
97
Halmark triad of urethral injury
Blood at urethral meatus Inability to void Distended bladder
98
Urethral injury treatment
Catheter and monitor Surgery in severe with maybe suprapubic catheter
99
Urethral injury imaging
RUG
100
Peyronie disease
Fibrotic changes in tunica albuginea leads to abnormal curvature
101
Peyronie disease pathophys
Trauma ISchemia Genetics
102
Peyronie disease treatment
Observation if <30º Pentoxifylline within 3 months Collagenase Clostridium histolyticum if >3 months
103
Priapism
Erection lasting over 4 hours
104
Priapism types
Ischemicc most common (very painful) Nonisechemic (related to trauma and less hard and painful)
105
Meds that can cause priapism
PDE-5 inhibitors Trazadone Antipsychotics Anticonvulsants Alpha blockers
106
Priapism diagnostic tesing
Carvenosal blood gas normal in high-flow, hypoglycemic, hypercarbic, and acidemia ain low-flow Doppler US to see blood flow
107
ischemic preapism treatment
Phenylephrine Needle aspiration Terbutaline Shunt surgery last resort
108
Nonischemic preapism treatment
Usually resolve in hours of days emobolization or surgical ligation if refrcatory
109
Balantitis
Inflammation of glans
110
Balantitis clinical findings
Inflamed glans Erythema Tenerness Edema Ulceration Exudate
111
Balantitis treatment
Topical nystatin (usually caused by candidia) Oral abx against anaerobes for severe with phimosis (usually bacterial)
112
Phimosis
Inability ot retract foresckin over glans Not an emergency
113
Phimosis pathophys
Distal scarring of foreskin after trauma, inflammation, or infection
114
Phimosis treatment
Hygiene Stretching foreskin 4-8 weeks topical CCS (hydrocortisone)
115
Paraphymosis
Retracted foreskin can't go back to normal position EMERGENCY
116
Paraphymosis treatment
Manual reduction Pharm therapy Definitive management
117
Penile fx treatment
Surgicla exploration within 48 hrs Evacuation of hematoma Repair lacerations Ligationo of vasculature
118
Most common penile cancer
Squamous cell carcimnoma
119
What is penile cancer associated with
HPV 6, 16,18 Smoking Lack of circumsision HIV
120
Bowen's disease
Leukoplakia on shaft of penis Associated with HPV 16 Sometimes leads to SCC
121
Penile cancer presentation
Skin abnormality or palpable mass Painless lump or ulcer Ulver on penis Most common on glans or coronal sulcus or prepuse Lymph node enlargement
122
Penile cancer diagnostic testing
Biopsy
123
Penile cancer treatment
Excision until clear margins Penile amputation
124
Erectile dysfunction causes
Vascular (atherosclerosis, diabetes, neuro, psycho, prolactinoma, trauma, surgery) Meds (BB, thiazides, spironolactone, CCB, SSRI, TCA)
125
`Erectile dysfunction diagnosis
History and PE Testosterone, CMP, CBC, A1C, lipid panel Nocturnal penile tumescence (sleep erections)
126
Erectile dysfunction treatment
PDE-5 inhibitor (-afil) Intracavernosal injections
127
How big is a healthy prostate
Walnut
128
What does BPH stand for
Benign prostate hyperplasia
129
BPH pathophys
Mechanical obstruction (intrusion into urethral lumen or bladder neck) Dynamic obstruction (Prostatic stroma made up of smooth muscle, collaen, and rich adrenergic nerve supply setting the "tone" of urethra)
130
BPH imaging
cystoscopy showing bladder diverticula and trabeculation
131
BPH presentation
Hesitancy (can't start stream) Decreased force of stream Sensation of incomplete bladder emptying Double voiding Straining to urinate Postvoid dribbling UTI Hematuria Renal insufficiency Irritative symptoms (urgency, freq, nocturia)
132
What to do if feel a nodule on prostate
US Prostate serum
133
BPH lab findngs
UA to exlude infection PSA (serum) to detect cancer Urine cytology if worried about bladder carcinoma
134
BPH treatment
AUA 0-7 - Observation Absolute surgery: Refractory urinary retention, large bladder diverticula, recurrent UTIs, revurrent gross hematuria, bladder stones, CKD Pts in between: alpha blockers 5-alpha reductase inhibitors, phosphodiesterase-5 inhibitors combotherapy
135
Common side effects of alpha 1 blockers
Orthostatic Hypotension Retrograde ejaculation
136
Alpha 1 blockers
Used for BPH Short acting (proosin) need dose titration Long acting (terazosin) once daily dosing and requires titratino
137
What med for BPH acts quickly
Alpha-1-blockers (-in)
138
What med can lower PSA
5-alpha-reductase inhibitors (-asteride)
139
What size prostate is best to use 5-alpha-reductase (-asteride) against
>30 grams
140
Side effects of BPH treatment
Decreased libido Decreased volume of ejaculate Erectile dysfunction Decrase serum PSA
141
BPH surgery gold standard
Transurethral resection of prostate
142
BPH indications for surgery
Pt not satisfied with med treatment alone Acute urinary retention Renal insufficiency Bladder stones Recurrent UTI Recurrent hematuria
143
Transurethral resection of prostate compllications
Bleeding urethral strictures Perforation of prostate capsule Tansurethral resection syndrome
144
Transurethral incision of prostate
More rapid and less morbid than transurethrla resection of prostate Lower rate of retrograde ejaculation
145
When to do in BPH when prostate is very large
SImple prostatectomy
146
Acute bacterial prostatitis most common causes
E. coli Pseudomonas
147
Acute prostatitis presentation
Perineal, sacral, or supbubic pain Fever ad chillls Irritative voiding complaints Urinary retention NV Warm prostate on DRE (hot and boggy)
148
Acute prostatitis labs
CBC shows leukocytosis with left shift UA shows pyuria
149
Acute prostatitis imaging
Pelvic CT or transrectal US who don't respong to treatment in 24-48 hrs
150
Acute bacterial prostatitis treatment
Ampicillin and aminoglycoside (IV) Switch to floroquinolones PO once afebrile for 24-48 hrs
151
When to refer someone with acute bacterial prostatitis
urinary retention or evidence of chronic prostatitis Signs of sepsis Need surgical drainage of bladdir prostatic abscess
152
Chronic bacterial prostatitis presentation
Irritative voiding symptoms Urethral pain Obstructive urinary sympoms Low back pain Perineal pain Asymptomatic between acute flares
153
Chronic bacterial prostatitis lab findngs
Postprostatic massage voided urine shows leukocytes (>5 per high power field) and bacteria growth when cultured No imaging needed
154
Chronic bacterial prostatitis treatment
Hospital for febrile IV ampicillin and gentamycin or third gen ceph or fluoroquinolone Outpatient: Oral bactrim or fluorquinolone for 4-6 weeks Symptomatic: Anti-inflammatories (indomethacin or ibuprofen, hot sitz bath, alpha-blockers (sin)
155
Non-bacteria chronic prostatitis lab findings
Increased leuocytes but cultures are negative
156
Non-bacterial chronic prostatitis treatment
ALpha-blockers
157
Prostate cancer presentation
Mostly asymptomatic Lymph node metastasis Hard, nodular, irregular prostate on DRE
158
What to do if DRE abnormal to test for prostate cancer
Trans rectal Ultrasound Biopsy
159
Prostate cancer lab findings
PSA >4 Greater means more severe
160
Prostate cancer imaging
CT to see nodal metasteses MRI to see prostate and regional lymph nodes PET scan
161
Prostate cancer treatment
Active surveillance for low PSA, small volume, or less than 10 year life expectancy Radical prostatectomy for T1 and T2 (T4 too far gone) Radiation (brachytherapy)
162
Brachytherapy
Implantation of permanent or temporary radioactive seeds into prostate Less risk of getting ED
163
Locally and regionally advanced prostate cancer treatment
Combo therapy with androgen deprivation and surgery or irradiatino
164
Metastatic prostate cancer treatment
Androgen deprivation therapy Meds that block pituitary, hypothalamus, adrenals, prostate cell
165
Hormone levels in menopause
FSH elevated Estradiol, progesterone, testosterone, AMH, inhibin B low Antral follicle count low
166
Early menopausal transition in perimenopause
>7 day change in intermenstrual interval FSH rises
167
Late menopausal transition in perimenopause
Skiped cycles, amenorrhea episodes 1-3 years before final menstrual period
168
Perimenopause presentation
Irregular cycles Vasomotor symptoms Insomnia, fatigue Depression, anxiety, cognition issues Vaginal dryness Decreased libido bone loss
169
Menopause presentation
Amenorrhea for >12 months Bone loss Vaginal dryness Dyspareunia Urinary symptoms More common UTIs Weight gain Decreased libido
170
Geniturinary syndrome of menopause
Vulvovaginal atrophy or atrophic vaginitis Usually appers after vasomotor symptoms Estrogen deficiency vauses decreased blood flow and decreased sex function
171
Estrogen deficiency long term consequences
Bone loss (osteopenia, osteoporosis) Increased risk of CVD bc of increased LDLs
172
What age does bone mineral density peak in men and women
30
173
Menopause bone loss preention
Estrogen Vitamin D, Calcium Diet Exercise Smoking cessation Pharm therapy with bisphosphonates
174
What is the most common cause of death in women
CVD
175
Supportive labs to diagnose menopause
FSH > 40 Low estradiol Generally not needed for pts >45
176
Who needs labs for diagnosis of menopause
History of PCOS Taking COCP (need to stop and measure 4 weeks later) Had hysterectomy or endometrial ablation need FSH
177
When to stop COCP
Stop oral in 45-49 bc increased risk of VTE
178
What hormones to give menopausal pt with uterus
Estrogen AND progesterone Unapposed estrogen would cause uterus to grow
179
What hormones to give menopausal pt without uterus
Estradiol
180
Special needs in menopause hormone therapy that have had ovaries removed
Need extra estrogen
181
Heavy bleeding after long symptom-free period in menopause diagnostic studies
TVUS and biopsy
182
Nonhormonal treatment of vasomotor symptoms of menopause
SSRI/SNRI Vaginal lubricants and moisturizers Gabapentin
183
Vitamin D functions
Ca absorption Muscle contraction Bone mineralization, growth, remodeling Cell growth Glucose metabolism Reduction of inflammation
184
Parathyroid hormone job
Control level of Ca in blood
185
Whole PTH
Intact PTH + fragmented PTH Best assay for end-stage renal
186
Hypercalcemia symptoms
Fragile bones More freq urination Increased thirst NV Fatigue Kidney stone
187
Hypocalcemia symptoms
Tingling in fingers/toes Muscle cramps Irregular Heartbeat
188
Estradiol characteristics
Strongest Most common until menopause Secreted by ovaries Assissts in lactation Maintain bone health
189
Estriol characteristics
Weaker than estradiiol Maintain estrogen during pregnancy Made by placenta Causes skin and hair to glow
190
What do low levels of estriol cause
Infertility Menstrual irregularities
191
Progesterone function
Maintain pregnancy
192
When is progesterone high
Ovulation and preg
193
When is progesterone low
infertility Placental failure Menopause
194
What lab can help find cause of abnormal uterine bleeding
Progesterone
195
What does high FSH cause
Hot flashes Weight gain Vaginal dryness Irregular menstration Sleep disturbance Bone loss
196
What does low FSH cause
Limited sperm productoion Infertility Delays in sex development
197
LH job in males
Signal testes to make testosterone
198
LH jobs in females
Control menstrual cycle Trigger ovulation Signal ovaries to make estrogen
199
What's elevated in PCOS
DHEA
200
What can elevated PRL cause
Low male sex drive and erectile dysfunciton Menstrual irregularities and infertility
201
Tumor marker for ovarian cancer
CA-125 in blood
202
Tumor marker for breast cancer
HER2 in females
203
What to aways screen for if also screening for STI
HIV Document if pt declines
204
How often to screen men who have sex wit men for STI
Every 3- 6months
205
Trichomoniasis
Protozoan STD
206
Most common nonviral STI worldwide
Trichomoniasis
207
Trichomoniasis clinical fidings
Asymptomatic in men Vaginal discharge Vulvovaginal discomfort Dysuria Dyspareunia Abd pain Vaginitis Cystitis Cervicitis
208
Trichomoniasis PE findings
Vaginal discharge Inflammation of vaginal walls and cervix Men asymptomatic maybe some urethral discharge
209
Trichomoniasis diagnostic testing
Wet mount microscopy showing organism
210
Trichomoniasis treatment
Metronidazole
211
What to tell people that take metronidazole
NO alcohol
212
Trichomonias complications
Cystitis Pelvis inflammatory disease Infertility Increased risk of HIV or transmission Prostatitis Epididymitis Slowed sperm
213
Trichomoniasis complications in preg
Premature ruptur of membranes Preterm birth
214
most commmon bacterial STI
Chlamydia
215
Chlamydia clinical findings
Urethritis Mucoid or watery discharge Dysuria Cerivicitis Vaginal bleeding
216
Chlamydia diagnostic studies
Nucleic acid amplification tests Gram stain
217
Who to screen. for chlamydia
Sexually active women 25 years or younger or have risk factors HIV Gay men
218
Chlamydia treatmnt
Doxycycline
219
What to warn someone taking doxycycline about
Sunburns
220
Chlamydia complications
Reactive arthritis (reiter's syndrome)
221
Gonorrhea clinical findings male
Urethritis Prurulent discharge Dysuria Can involve prostate, epididymis, and periurethral glands
222
Gonorrhea clinical findings female
Cervicitis Mucopurulent discharge Dysuria Increased urinary freq and urgency
223
Gonorrhea conjunctivitis
Direct inoculation to conjunctiva (touch infected genitals then touch eye) Prurulent drainage NAAT swab from conunctiva Refer to opthalmology Can lose eye if not treated
224
Gonorhea diagnostic test
Nucleic acid amplification testing
225
Gonorrhea treatment
Ceftriaxone IM (resistant to penicillin, doxy, and cipro)
226
Gonorrhea complications
Prurulent arthritis Rash Tenosynovitis Tubo-ovarian abscess Pelvic inflammatory disease Urethral stenosis in male Systemic infection
227
Gonnorhea prevention
Condoms Doxycycline postexposure prophylaxis
228
Bacterial vaginosis clinical findings
Discharge Grey color Fish odor No inflammation
229
Bacterial vaginosis diagnostic studies
Wet mount with clue cells (adherence of gardnerella vaginalis to epithelial cels Whiff test (KOH increase fish odor) pH >4.5
230
bacterial vaginosis treatment
Metronidazole Alternative: clindamycin
231
HSV pathophys
Virus goes dormant in dorsal root ganglion Infection lifelong
232
HSV clinical findings
Painful vesicular lesions on genitals Regional lymphadenopathy Flu-like symptoms Dysuria Neualgia maybe
233
HSV diagnostic studies
PCR best Direct fluorescent antibody fast
234
HSV treatmnt
acyclovir
235
What to do if preg has HSV and symptoms during labor
DO NOT give vaginal birth
236
What bacteria causes chancroid
Haemophilus ducreyi
237
Chancroid epidemiology
STI usually from carribean or africa
238
Chancroid clinical findings
Deep, painful genital ulcer with well defined irregular borders Heavy, foul discharge Erythematous Painful inguinal lymphadenopathy Bubeos
239
Chancroid diagnostic studies
Clinical diagnosis Difficult to culture Rule out HSV and syphilis
240
Chancroid treatment
Azithromycin Treat partners
241
Granuloma inguinale (donovanosis) cause
Klebsiella granulomatis (encapsulated G-)
242
Granuloma inguinale (donovanosis) clinical findings
Painless nodules then slough off forming ulcers with granulation and easy bleeding Can spread from genitalia to lower abd and thigs Tender lymphadenopathy
243
Granuloma inguinale (donovanosis) lab studies
Wright stain with dark staining of donovan bodies and bacteria encapsulated macrophages Biopsy if stain negative
244
Granuloma inguinal (donovanosis) treatment
Azithromycin or doxy Treat partners
245
What bacteria cauases lymphogranuloma venereum
Chlamydia trachomitis (L1-L3)
246
Lymphogranuloma venereum clinical findings
Self limited ulcer Buboes Proctocolitits Fever, chills HA Arthralgia Abd cramps
247
Lymphogranuloma venereum diagnostic studies
Nucleic acid amplification tests LGV specific molecular tests
248
Lymphogranuloma venereum treatment
Doxycycline or erythromycin Treat partners
249
Bacteria that causes syphilis
Treponema pallidum
250
Primary syphillis clinical finidngs
Chancre (painless ulcer with clean base and firm indurated borders) Regional lymphadenopathy (painless and rubbery)
251
Secondary syphilis clinical findings
few weeks to 6 months after chancre Macropopular rash patchy alopecia Hepatitis Nephritis Palms and soles Arthralgias Fever
252
Late tertiary syphilis clinical presentation
> 1 year after contact Without active lesions Gummatous lesion at skin, bones, viscera, ocular, CNS, CVD
253
Neurosyphilis
Life threatening complication of syphilis Chronic meningnitis AMS Argyll-Robertson pupil
254
Argyll-robertson pupil
Neurosyphilis treatment Bilateral small irregular pupils that constrict with accomodation but not when exposed to light
255
Syphilis diagnostic testing
Dark field microscopy Fluorescent treponemal antibody tests confirmatory
256
Syphils treatment
Benzathene Penicillin G IM Treat recently exposed contacts
257
Condyloma acuminata clinical findings
Warts on perianal skin that can extend into anal canal that can be flat or look like cauliflower Itching, bleeding, or pain
258
Condyloma acuminata cause
HPV (usually 6 or 11)
259
Condyloma acuminata prevention
HPV vaccine
260
Condyloma acuminata diagnostic studies
Clinical diagnosis Biopsy if unsure to rule out cancer
261
Condyloma acuminata treatment
Cryotherapy Surgical excisioon Trichloroacetic or bichloroacetic acid
262
Pevic inflammatory disease causes
N gonorrhea C trachomatis Anaerobes H influenza Strep G- rods
263
Pelvic inflammatory diseas risk factor
Sex Recent IUD placement
264
Pelvic inflammatory disease clinical findings
Lower abd pain Uterine bleeding Vaginal disharge Fever Abscess RUQ pain
265
Pelvic inflammatory disease Pelvic exam findings
Uterine, cervical, or adnexal tenderness Cervical motion tenderness (chandelier sign)
266
Pelvic inflammatory disease diagnostic testing
ORal temp > 101 Abnormal vervical or vaginal discharge Increased WBC Elevated ESR or CRP Cervical motion tenderness or adnexal tenderness Rule out preg Nucleic acid smplification test for (N gonorrheoea or C trachomatis)
267
Pelvic inflammatory disease treatment
Ceftriaxone + doxycycline + Metronidazole
268
Pelvic inflammatory disease surgery indications
Tubo-ovarian rupture or >8cm Poor response to to abx in 48 hrs
269
What surgery is used for pelvic inflammatory disease with overwhelmic infection
Hysterectomy and bilateral salpingo-oophorectomy
270
Pelvic inflammatory disease complications
Fitz-Hugh Curtis syndrome (perihepatitis and infalammation of liver capsule and peritoneal surface of RUE)
271
Parous
Cervix that is regularly open
272
Nabothian cyst
White/opaque cystic structure on cervix Normal finding May come from childbirth trauma
273
Ectropion
Eversion of endocervix exposing columnar epithelium Could be after childbirth or COCPs No management unless spotting or discharge
274
Cervical polyps
Small benign peducnculated tissue originating from endocervix Reddish purple, smooth protrusion orom cervical os with pedicle Intermenstrual or postcoital bleeding
275
Cervical polyp management
Removal via speculum exam Large may need to be in OR
276
Most common STI
Human papilloma virus (HPV)
277
What versions of HPV are high risk for cancer
16 and 18
278
What versions of HPV are low risk for cancer
6 and 11
279
How does HPV spread
Sex Fingers, mouth, skin Vertical (mother to child)
280
HPV prevention
Vaccine recommended for 11-45 yo
281
HPV presentation
Asymptomatic Anogenital condylomas (warts) Abnormal cytology on screening Vervical, vulvular, anal, oropharyngieal, or rectal cancer
282
Condyloma
Wart
283
Condyloma acuminata
Anogenital warts caused by HPV through anogenital contact Cauliflower-like Can be on vulva, vagina, cercvix, oropharynx, perineum, or rectum
284
Condyloma diagnostic studies
Usually clinical Biopsy if unsure
285
Condyloma acuminata treatment
Limquimoid cream TID FIRST LINE Podophyllotoxin cream Cryotherapy, electrosurgery, or trichloroacetic acid Surgery for large
286
How to screen someone <21 years old for HPV
Don't
287
How to screen someone 21-29 for HPV
Cytology every 3 years
288
How to screen someone 30-60 for HPV
Cytology every 3 years or hrHPV every 5 years or Both
289
How to test someone >60 for HPV
Don't have to if don't have history
290
How to screen someone with hysterectomy for HPV
Don't have to unless history or history of cancerous lesions on cervix
291
Colposcopy
Looks at entire tissue of cervix Put acetic acid on cervix and abnormal cells look white Iodine applied and abnormal cells are yellow
292
Cytologic and histologic findings of HPV
Squamous lesions Glandular lesions Cervical neoplasms (scored 1-3)
293
ASC-US
Cervix Atypical squamous cells of undetermined significance
294
LGSIL
Cervix Low grade squamous intraepithelial lesion
295
ASC-H
Cervix Atypical squamous cells, cannot rule outhigh grade changes
296
HSIL
Cervix High grade intraepithelial lesion
297
ASC-US and high risk of HPV negative treatment
Repeat screening at normal intervals
298
ASC-US and high risk of HPV positive treatment
<25 repeat in 1 year >25 colopscopy
299
ASC-H treatment
Colopscopy
300
LGSIL treatment
<25 repeat in one year
301
LGSIL and negative high risk HPV treatment
>25 repeat in one year
302
LGSIL and positive high risk HPV treatment
>25 colopscopy
303
HGSIL treatment
Colopscopy Surgery maybe if >25
304
Atypical glandular cells treatment
Colopscopy Endometrial sampling if >35 years
305
Adenocarcinoma in citu treatment
Colopscopy Endometrial sampling if >35 years
306
Endometrial cells on cervical cancer screening treatment
Premenopausal: routine screening Menopausal: not normal need colposcopy
307
No endocervical cells on cervical cancer screening treatment
Repeat screening at normal intervals
308
Most common cervical cancer
Squamous cell
309
Cervical cancer risk factors
HPV Smoking Low socioeconomic status
310
Cervical cancer presentation
Asymptomatic Visible lesions on pelvic exam Vaginal bleeding Postcoital bleeding Vaginal discharge (water, mucoid, malodorous)
311
Cirvical canver management
Conization for diagnosis and treatment if want to preserve fertility Hysterectomy preferred Lymphadenedecomy, radiation, or chemo for greater stage
312
Vulvar lichen simplex chronicus
Benign epithelial thickening and hyperkeratosis from chronic irritation
313
Vulvar lichen simplex chronicus causes
Soaps Perfumes Detergent Pads Infection Allergies
314
Vulvar lichen simplex chronicus Presenation
Scratching vulva Tissue appears thickened Deep red or white plaques
315
Vulvar lichen simplex chronicus treatment
Identify and stop offending agents Sitz baths Lubricants Oral antihistamines Topical steroids
316
Lichen sclerosis
Benign, chronic, progressive inflammation of epithelial lining and pruritis
317
Lichen sclerosis causes
Genetics Maybe autoimmune Low estrogen (prepubital/postmenopausal)
318
Lichen sclerosis presentation
Pruritis of vulva Dysuria from fissuring Dysparunia Spotting, bleeding White plaques Thin white skin Agglutination f labia minor and clit
319
Lichen sclerosis diagnostic studies
Usually clinical Biopsy showing thin hyperkeratotis layer, thinning of epithelial layer, and deep lymphocytic infiltration
320
Lichen sclerosis treatment
Hygiene Stop irritants Sitz baths Lubricants Oral antihistamine Topical potent steroid If those don't work: Tacrolimus cream Photodynamic therapy Intralesional steroids
321
Vulvar Lichen planus etiology
Autoimmune related
322
Vulvar lichen planus presentation
Vulvular pain, discomfort, soreness Burning and dysuria Spotting or bleeding Irritating vaginal discharge Sharply demarcated erythamous erosions glazed
323
Vulvar livhen planus diagnostic studies
Biopsy Rule out cancer
324
Vulvar lichen planus treatment
No cure Topical super potent steroids
325
Atrophic vaginitis other name
Genitourinary syndrome of menopause
326
Atrophic vaginitis cuase
Low estrogen decreases bloodflow and lubrication
327
Atrophic vaginitis presentation
Asmptomatic Dyspareunia Vaginal dryness Vulvar irritation Recurrent UTIs Pale,dry, shiny epithelium Maybe fissures Prominent urethra
328
Atrophic vaginitis diagnostic studies
Clinical
329
Atrophic vaginitis treatment
Lubricants (coconut oil or water based) Vaginal estrogen Vaginal moisturizers (hyaluronic acid)
330
Vulvovaginal candidiasis pathogen
Candida albicans Candida glabarata
331
Vulvovaginal candidiasis risk factors
DM (from SGLT2) broad spectrum abx Elevated estrogen levels Immunosuppression
332
Vulvovaginal candidiasis presentation
Vulvar pruitiss White discharge Vulvar erythema Labia minora edema Burning after urination
333
Vuluvovaginal caandidiasis diagnostic studies
Microscopy shows candida (budding yeast)
334
Vaginal candidiasis treatment
Oral flucanazole or Topical terconazole (less side effects) 2nd line: ibrexaafungerp
335
Vulvar cancer risk factor
TOBACCO USE HPV
336
Vulvar candidiasis in preg treatment
Clotrimazole Miconazole Nystatin
337
Vulvar cancer clinical manifestation
Asymptomatic Vulvar pruritis Vulvar mass Bleeding Pain Hx of infrequent pelvic exam
338
Vulvar cancer diagnosis
Biopsy
339
Vulvar cancer treatment
Wide excision with inguinal lymph node dissection
340
Vaginal cancer risk factros
HPV Smoking DES exposure
341
Most common vaginal cancer
Squamous cell carcinoma
342
Vaginal cancer presentation
Asymptomatic Vaginal bleeding Discharge Mass
343
Vaginal cancer diagnostic studies
Cytology Colposcopy and biopsy
344
Bartholin gland cyst and abscess most common pathogen
E. coli
345
Bartholin gland cyst presentation
Can be asymptomatic Painful Diff sitting, ambulating, intercourse Clear or white drainage
346
Bartholin gland abscess presentation
Localized severe pain Edema Erythema Fever Mucopurulent drainage
347
Bartholin cyst treatment
Rule out cancer Warm compresses and sitz baths for <3cm Incision and drainage with culture and word catheter or maybe surgical marsupialization for >3cm
348
Bartholins abscess treatment
Incision and drainage and culture Word catheter for one month
349
Bechets syndrome presentation
Like HSV but tests HSV negative Oral aphthous ulcers Vulvar aphthous ulcers Uveitis GI disease Nephritis Thrombosis
350
Bechet's syndrome treatment
Refer to rheumatology Corticosteroids for vulvar
351
Imperforate hymen presentation
Budging introitus during infancy Adolescents with amenorrhea
352
Imperforate hyment diagnostic studies
Ultrasound
353
Imperforate hymen treamtne
Hymenectomy
354
Most common vaginal foreign body
Tampon
355
Vaginal foreign body presentation
Chronic vaginal discharge Intermittent bleeding or spotting FOul smelling odor
356
Mittleschmerz
Ovulation pain
357
Most common ovarian cyst
Follicular cyst
358
Types of ovarian cysts
Follicular cysts Corpus luteal cysts (granulas lutein) Endometrioma (chocolate cyst)
359
What causes follicular cyst
Failure in ovulation after follicular phase
360
Follicular cyst clinical manifestation
Asymptomatic Usually incidental finding Large ones have pelvic pain and dyspareunia
361
What causes corpus luteum cyst
arise from resorption of blood from corpus luteum
362
Corpus luteal cysts presentation
Thin walled unilocular cyst Local pain and tenderness Amenorrhea Delayed menstruation Torsion of ovary Rupture has results in peritoneal signs, acute abd, and shock
363
Ovarian teratoma
Dermoid cyst, germ cell tumor, benign ovarian neoplasm Have hair and teeth tissue Heavy
364
Ovarian cyst diagnostic studies
Ultrasound
365
Ovarian cyst treament
Usually resolve themself Ultrasound x3 months for follicular Remove if problems
366
ovarian torsion causes
Ovarian cyst OVarian neoplasms preg
367
Ovarian torsion presentation
Pelvic pain Ovarian mass Nasea/vomiting
368
Ovarian torsion diagnostic studies
palpable masses Pelvic ultrasound show follicular shift Urine beta HCG
369
Most common cause of infertility
PCOS
370
PCOS pathophys
Abnormal gonadotropin releasing hormone pulse freq Over production of LH and fSH Increased testosterone Hyperinsulinemia Decreased sensitivity to insulin
371
PCOS presentation
Menstrual irregulariaties Hyperandogenism (hirstuism, acne, male pattern hair loss) Polycystic ovaries Obesity Infertility
372
PCOS diagnostic criteria
Rotterdam criteria need 2/3: Oligo or anovulation Clinical labs with signs of hyperandrogenism Polycystic ovaries by ultrasound
373
PCOS diagnostic studies
String of pearls or oyster ovaries seen on US
374
PCOS treatment goals
Fertility Manage metabolic problems Imrpove hyperandrogenic features Prevention of endometrial hyperplasia
375
PCOS treatment
Lifestyle COCPs (progestin only if COCP contraindicated) Spironolactone if no improvement (not for preg) Manage insulin resistance
376
PCOS complications
Endometrial hyperplasia Endometrial carcinoma Cardiovascular disease Diabetes Infertility
377
Tuboovarian abscess etiology
Ascending polymicrobial infection causing inflammatory mass of fallopian OFten seen in PID, STI, GI infection, Appendicitis, Bowel surgery
378
Tuboovarian abscess etiology
Multiple sex partners 15-25 yo Prior hx of PID Immunosupresion
379
Tuboovarian abscess presentation
Unilateral abd pelvic pain Fever, chills NV
380
Ruptured tuboovarian abscess presentation
Abd pain Peritonitis Septicemia Shock
381
Tubuoovarian abscess diagnostic studies
Unilateral mass US showing complex mass that obliterates normal adnexal architecture
382
Stable tuboovarian abscess treatment
IV broad spectrum abx (ceftriaxone +doxy+metro) then transition to oral Minimally invasive drainage if >7cm or if concern for malignancy in post-menopausal
383
Ruptured tuboovarian abscess treatment
Surgical laparotomyurgery Sepsis, >7cm
384
Tuboovarian cyst complications
Adhesions INfertility (from adhesions) Ectopic preg Bowel obstruction
385
Deadliest GYN cancer
Ovarian
386
Most common ovarian cancer
Epithelial Very serious
387
OVarian cancer presentation
Bloating Early satiety Pelvic/abd pain Urinary freq and urgency Ascites Pleural effusion Bowel obstruction VTE
388
OVarian cancer diagnostic studies
Adnexal mass on physical exam US
389
What imaging is best to assess metastasis of ovarian cancer
CT or MRI
390
Ovarian cancer tratment
Surgical resection Chemo Radiation
391
Genetic causes of ovarian cancer
BRCA Lynch
392
Primary ovary insufficiency
Hypogonadism <40 yo
393
Primary ovarian insufficiency causes
Ovarian surgery Radiation Chemo Primary adrenal insufficiency Autoimmune Fam history Fragile
394
Primary ovarian insufficiency symptoms
Oligomenorrhea or amenorrhea Hot flashes Night sweats Vaginal dryness
395
Primary ovarian insufficiency diagnostic studies
Low estradiol Elevated FSH Negative TSH
396
Primary ovarian insufficiency treatment
Estradiol PO or patch with progesterone
397
Abnormal uterine bleeding pathophys
Mess up in HPA axis Anatomic issue Coagulopathies
398
What to ask about abnormal uterine bleeding
Age (could be cancer in post-menopausal) Days between cycles Spotting between cycles How heavy Clots? (amount and size) Pads/tampons per hour Cramps
399
Abnormal uterine bleeding work up
Physical exam HCG TSH CBC Pelvic ultrasound
400
Abnormal uterine bleeding diagnosis
Exclusion
401
Abnormal uterine bleeding treatment
Birth control Transexamic acid NSAIDs Myoectomy if want to preserve fertility Endometrial ablation Uterine artery embolization Hysterectomy
402
Endometriosis
Presence of endometrial tissue outsiede uterine cavity Commonly in pelvis but can occur anywhere
403
Endometriosis presentation
Peritoneal adhesions Ovarian cysts Endometriotic nodules (usually between rectum and vagina) Non classic lesions (red or clear vesicles)
404
Endometriosis etiology
Retrograde menstruation and refluxed menstrual tissue
405
What increases risks of endometriosis
Fam history Nulliparity Early menarche Late menopause
406
Endometriosis symptoms
Chronic pelvic pain Pressure (throbing, dull, sharp, burning) Dysmenorrhea Dyspareunia Dyschezia Urinary probs GI pain Abnormal uterine bleeding Diff achieving preg Infertility Can be asymptomatic
407
Endometriosis diagnostic studies
Transvaginal US initial Laparoscopy showing lesions is DIAGNOSTIC Get biopsy of lesions
408
Endometriosis physical exam findings
Nodules in posterior fornix Adnexal masses (from chocolate cysts/endometrioma) Immobility of cervix Can be normal
409
Endometriosis surgical indications
Pain limits funiction Medical management doesn't work Treatment of ovarian cysts, rectovaginal nodules, bladder lesions
410
Fitz Hugh Curtis Syndrome
Adhesions from liver to anterior abdomen Seen in endometriosis
411
Endometriosis treatment
NSAIDs Hormonal contraceptives Refer to fertility specialist if want 2nd GnRH analogs (leuprolide IM monthly) Laparoscopy with excision of implants and adhesions
412
Leiomyoma
Noncancerous tumor arising from smooth muscle cells of myometrium
413
Most common pelvic neoplaasm in females
Leiomyoma
414
Leading cause of US hysterectomies
Leiomyoma
415
Leiomyoma presentation
Heavy or prolonged menstrual bleeding Pelvic pain and pressure Dyspareunia Dysmenorrhea Reproductive dysfunction Urinary retention or obstruction Constipation Could be asymptomatic if small
416
Leiomyoma diagnostics
Transvaginal US Consider MRI CBC
417
Leiomyoma treatment
NSAIDs, COCPs, progestin IUDs, TXA GnRH agonist if those don't work Uterine artery emobolization if don't care about fertility Myomectomy Hysterectomy
418
Tranexamic acid (TXA)
Treatment for leiomyoma Take only during menses
419
When to use NSAIDs in leiomyoma
Heavy bleeding Start on first day of menses and continue 2-3 days or until menses end
420
When is hysteroscopic myomectomy indicated
Submucosal fibroids
421
Hysterectomy indications
Abnormal uterine bleeding FIbroids/leiomyomas Adenomyosis Endometriosis Uterine prolapse
422
When to do abdominal hysterectomy
Very large mass
423
Hysterectomy post-op instructions
Nothing goes into vagina for 6 weeks or until cleared Don't lift over 13 lbs
424
Adenomyosis
Endometrial glands and stroma present within myometrium
425
Adenomyosis symtoms
Heavy menstrual bleeding Dysmenorrhea Chronic pelvic pain Fertility probs Can be asymptomatic
426
Adenomyosis physical exam findings
Mobile uterus Diffusely enlarged and globular Boggy Tender
427
Adenomyosis dianostic studies
Trasnvaginal ultrasound initial showing enlarged uterus, asymmetryic thickening of myometrium, myometrial cysts, hyperechoic island of tissue, increased myometrial heterogenety Pathology is diagnostic
428
Adenomyosis treatment
1st NSAIDs, levonorgestrel IUD 2nd COCPs, GnRH analogs Hysterectomy if need surgery
429
Who commonly gets endometrial hyperplasia
Perimenopausal or menopausal
430
Benign endohyperplasia diagnostic imaging
Transvaginal ultrasound initial with endometrila stripe >4mm in menopausal Endometrial biopsy diagnostic
431
Endometrial hyperplasia treatment
Progestin therapy Dilation and curettage Hysterectomy
432
Most common gyn malignancy
Endometrial cancer
433
Most common endometrial cencer
Adenocarcenoma
434
Endometrial cancer risk factors
Unopposed estrogen replacement therapy Tamoxifen Chronic anovulation Obesity Early menarche and late menopause Lynch syndrome BRCA carrier
435
What can be protective against endometrial cancers
Oral contraceptives Increased amount of pregnancies Breast feeding
436
Endometrial cancer presentation
Abnormal uterine bleeding Abnormal cervical pathology Incidental finding on imaging (most asymptomatic)
437
Endometrial cancer diagnostic studies
Transvaginal ultrasound INTIAL with endometrial thickness > 4mm Biopsy GOLD standard
438
Tumor marker related to endometrial cancer
CA125
439
Endometrial cancer treatment
Hysterectomy Lymph node evaluation to guide adjunct chemotherapy
440
Asherman syndrome
Intrauterine adhesions Usually after procedure
441
Asherman syndrome presentation
Secondary amenorrhea Infertility
442
Asherman syndrome imaging
INITIAL transvaginal ultrasound GOLD hysteroscopy
443
Pelvic floor dysfunction symptoms
Urologic probs Gynecologic probs Colorectal probs Discomfort Body image issues
444
Pelvic organ prolapse risk factors
High birth weight, prolonges second phase of labor, maternal age>25 Age (60-70) Overweight Constipation COPD Lifting jobs
445
Pelvic organ prolapse prevention
Weight loss Managing constipation or cough
446
Pelvic organ prolapse quantification staging
Stage 1: 1cm above hymenal remnants Stage 2: 1cm above to 1cm below hymenal remnants Stage3: > 1cm past hymenal remnants but nt complete eversion Stage 4: Complee vaginal vault eversion/complete uterine procidentia
447
Pelvic organ prolapse treatment
Nothing if no symptoms or pt okay with symptoms Conservative 1st (pelvic floor physical therapy, big tampon thing, vaginal pessary) Vaginal pessary is mainstay Surgery if refuse (hysterectomy)
448
Vaginal pessary contraindications
Infection Noncompliance Mesh exposure Sexually active and unable to remove Silicone allergy
449
Vaginismus
Involuntary muscle spasm with vaginal prenetration
450
Vaginismus diagnosis
Exclusion Physical exam Vulvar q tip testing Check pudendal nerve for neuralgia, compression, or entrapment
451
Vaginismus treatment
Hygiene, stress redcution, lubricant, espom bath Pelvic floor PT, CBT, sex counseling TOpical lidocain, estradiol cream Amitryptyline Gabapentin Diazepam suppository
452
Vulvodyna
Vulvular pain of unknown cause of last three months
453
Vulvodynia classifications
Location if localized (vestibulodynia, clitorodynia) or generalized Can be provoked by contact
454
Vulvodynia presentation
Pain with intercourse, tampon insertion, tight clothes, sitting for long time
455
Vulvodynia treatment
Hygiene, stress redcution, lubricant, espom bath Pelvic floor PT, CBT, sex counseling TOpical lidocain, estradiol cream Amitryptyline Gabapentin Diazepam suppository
456
Myofascial pelvic pain syndrome
Chronic pelvic pain
457
Myofascial pelvic pain syndrome diagnosis
Based on phsical exam Trigger points identified like a clock
458
Myofascial pelvic pain syndrome treatment
Hygiene, stress redcution, lubricant, espom bath Pelvic floor PT, CBT, sex counseling TOpical lidocain, estradiol cream Amitryptyline Gabapentin Diazepam suppository
459
Pudendal neuralgia causes
Compression, entrapment, inflammation Long car rides Surgery Bike riding
460
Pudendal neuralgia presentation
Acute, nerve associated pain
461
Pudendal neuralgia treatment
Pelvic floor PT Pudendal nerve block (lidocaine into area of ischial spine) Pregabalin Amitryptyline
462
Dyspareunia
pain with sexual penetration
463
Meds influencing sexual function
Antihypertensives Anticholinergics SSRI Antipsychotics
464
Erectile disorder
Difficulty obtaining an erection or marked decrease in erectile rigidity for > 6 months
465
Erectile disorder underlying etiology
Cardiovascular disease Prostatectomy Radiaton SSRI use
466
Erectile dysfunction treatment
PDE5 inhibitors (-afil) Vacuum erection devices Alprostadil injection Penile prostheses penile revacularization
467
Premature ejactulation treatment
SSRIs (paroxetine) Topical anesthetic
468
Female orgasmic disoreder comorbitities
MS Pelvic nerve damage from hysterectomy Spinal cord injury Vulvovaginal atrophy
469
Female orgasmic disorder treatment
CBT Fibanserin Bremelanotide Scream cream
470
Breast mass diagnostic studies
Breast exam Mammogram with ultrasound if >30yo Just ultrasound good for <30yo Biopsy if needed
471
What often causes false negative in mamogram
Denser breasts
472
Mastalgia
Breast pain Can be related to cycle (worse at ovulation) Noncyclic likely from mass Can be referred to chest wall (pec major injury)
473
What to do for bilateral diffuse breast pain
Reassurance Likely nothing bad
474
What to do for focal breast pain
<30 yo breast US >30 yo mammogram and breast US
475
When to be more conscerned about nipple discharge
Unilateral or single duct Bloody Spontaneous Or male
476
Meds that can cause nipple discharge
Antihypertensive GI agents Hormones Opiates Psychotic agents
477
What to labs to test in galactorrhes
Preg test Prolactin Renal Thyroid
478
Nipple discharge workup
Mammogram and US for >30yo US alone for <30yo Skin punch biopsy to rule out Paget disease of breast
479
Most common cause of Bloody nipple discharge
intraductal papilloma
480
Intraductal papilloma
Benign. papillary growths in ducts of breeath Cause bloody nipple discharge a lot of the times Incidentally found on imaging
481
Intraductal papilloma treatment
Excision bc often find breast cancer
482
Nipple discharge treatment
Stop causing med if possible Stop manipulating breasts Treat infection or cancer if present Surgery for high risk lesion
483
Fibrocystic breast disease
Most common benign breast disorder Multiple painful or painless breast cyst that may increase/decrease in size with menstrual or hormonal changes
484
Fibrocystic breast disease diagnostic studies
Breast US initial Fine needle aspiraqtion shows green or straw colored fluid (usually not needed)
485
Fibrocystic breast disease treatment
Reasurance NSAIDs sports bra (without wire)
486
Fibroadenoma
Benign solid tumor of glandular and fibrous tissue Usually nontender Gradually grow Don't change in size with menstrual cycle Firm, nodular, freely-mobile, maybe tender
487
Fibroadenoma diagnostic studies
US if<30 shwoing well defined hypoechoic masses Mammogram if >30
488
Fibroadenoma treatment
<2cm US every 6 months showing >2cm or fast growing Excision
489
Phyllodes tumor prsentation
Fibroepithellial breast tumor Smooth, multinodular, well defined, firm mass that is mobile and painless Rapidly increasing in size
490
Phyllodes tumor diagnostic studies
US or mammorgram Biopsy confirmatory
491
Phyllodes tumor treatment
Complete excision of mass
492
Drugs that cause gynecomastia
Spironolactone H2 blockers 5-alpha reductase Prednisone
493
Gynecomastia treatment
Stop offending med Tamoxifen Surgery if bothersome and present for >6months
494
Mastitis
Inflammation of breast tissue
495
Breast abscess
Localized collection of inflammatory exudate in breast tissue Complication of mastitis
496
Pathogen most related to mastitis
Staph aureus
497
Mastitis treatment
NSAIDs Warm/cold compresses Anti-staph abx (dicloxacillin, cephalexin, or erythromycin)
498
Who is at high risk for periductal mastitis
Smokers
499
Periductal mastitis treatment
Abx/aspiration of abscesses Repeat episodes need duct excision
500
Breast abscess presentation
Localized, painful, fluctuant mass Fever Malaise
501
Breast abscess treatment
US guided aspiration or I&D
502
Abscess complications
Commonly associated with underlying malignancy
503
Galactocele
Milk retension cyst
504
Galactocele presentation
Cystic masses during pregnancy, lactation, or after weaning
505
Galactocele diagnostic imaging
US with well defined lesion with thin echogenic walls and fat/fluid level Fine needle aspiration diagnostics
506
Epidermal inclusion cyst
Cyst that can be anywhere but someties seen on breast Skin colored with central punctum
507
Epidermal inclusion cyst treatment
I&D and abx Excision in high risk of infection
508
Hidradentitis suppurative of the breast
Inflammatory condition of apocrine sweat glands Associated with infection and abscess formation of axilla or skin of breast
509
Breast hematoma treatment
Ice, tyenol, wear good supportive bra
510
Fat necrosis presentatin
Palpable abnormality/lump often after surgery or trauma
511
Fat necrosis diagnostic imaging
Mammography and ultrasound May need biopsy to confirm
512
Intertrigo
Inflammation of site of two opposed skin surfaces Recurrent in women with large ptotic breasts affecting skin of lower half of breasts Fungal infections often presnt
513
Intertrigo treastment
Nyastatin powder
514
Complex sclerosing lesions/radial scars findings and treatment
Discovered incidentally when radiologic abnormality removed or biopsied Surgical excision
515
Atypical ductal hyperplasia
Premalignant accumulation of abnormal cells in milk ducts
516
Atypical ductal hyperplasia treatment
Excision
517
Three things that significantly increas pts lifetime risk of breast cancer
Atypical ductal hyperplasia Atypical lobular hyperplasia Lobular carcinoma in situ
518
What does hormone replacement cause in the breast
Enlargement Increases risk of breast cancer slightly
519
What genetic mutation is most linked to breast cancer
BRCA1 and BRCA2
520
Breast cancer presentation
Mass (mostly UOQ) Discharge usually bloody, rashes, retraction Edema Dimpling Palpable axillary and subclavicular nodes Pain Mastalgia Mass can turn into wound if not treated
521
Pagets disease of the breast presentation
Scaly, raw, vesicular, or ulcerated lesion that starts at nipple and spreads to areol Pain, burning, and/or pruritis
522
Paget's disease diagnostic studies
Skin punch biopsy
523
Paget's disease management
Nipple-areolar complex and underlying cancer must be excised
524
Inflammatory breast cancer presentation
Warm, swollen, red, itchy breast Maybe nipple retraction Papable lump Satelite lesions
525
Inflammatory breast cancer treatment
Chemotherapy and mastectomy, axillary dissection
526
Breast cancer staging
T: tumor (localized) N: node (lymph node involvement M: metastasis
527
Indicators of Breast cancer growth
ER PR HER2 (faster growth) Oncotype
528
Triple negative
Negative for ER, PR, and HER2 Agressive Less treatment options
529
Breast cancer staging imaging
Stage III needs full body PET or CT scan Maybe bone scan
530
Breast cancer treatment options
Local: surgery (mastectomy or lumpectomy) or radiatoin Systemic: hormone, chemo, targeted immune modulating
531
Mastectomy
Removal of entire breast
532
Modifed radical mastectomy
Removal of entire breast and all axillary lymph nodes, Not pec muscle
533
Tamoxifen use and side effects
Used in pre-menopause to reduce recurrence of breast cancer Cause hot flashes, mood swings, fatigue, nausea
534
Aromatase inhibitos use and side effects
Used in post-menopause to reduce recurrence of breast cancer Cause hot flashes, mood swings, fatigue, nausea
535
LNRH agonist use
Treat pre-menopausal breast cancer. Shut down ovaries to stop estrogen production
536
What meds to use for HER-2 breast cancer
Trastuzumab
537
What lumpectomy margins do we want
>2mm
538
Fecundability
Probability of achieving pregnancy in one menstrual cycle
539
Sterility
Ability to achieve pregnancy
540
Most common cause of infertility in women
Ovarian dysfunction PCOS most common of that
541
Most appropriate initial step in evaluation for infertility
History and physical exam of both partners
542
Infertility definition
No conception after 12 months of unprotected sex
543
Infertility treatment for anovulatory woman
Clomiphene citrate
544
Infertility treatment for womana with abnormal postcoital test
Artificial insemination
545
Infertility treatment for woman with PCOS
Glycemic index diet, exercise, weight loss Metformin
546
Infertility treatment for woman with endometriosis
Laparascopic removal of adhesions
547
INfertility treatment for woman with uterina anomalies
Hysteroscopic resection
548
What types vaccinations are contraindicated in pregnancy
Live
549
CMV presentation in preg and treatment
Cytomegalovirus Gancyclovir
550
Toxoplasmosis presentation in preg and treatment
Intracranial calcifications Hydrocephalus Sulfadiazine + leucovorin
551
Syphilis presentation in preg and treatment
Maculopapular rash on palms and soles, sniffles, periostitis Penicillin
552
Rubella presentation in preg and treatment
Cataracts, deafness, heart defects, PDA No treatment
553
How long is full term pregnancy
>37 weeks
554
How long is preterm pregnancy
20-36 weeks
555
How llong is post-term pregnancy
>42 weeks
556
What HCG levels is a sign of pregnancy or possibly ectopic pregnancy
>1500
557
Exercise restrictions in pregnancy
No supine exercises (kinks IVC) 30 mins/day good
558
Cardiac changes in pregnancy
Cardiac output increases by 50% by week 8 (20% of that goes to uterus) Increases risk of post-partum hemorrhage Diastolic BP increases in 7th week up to 10mmHg Pulse increases 10-18bpm Diastolic murmur NOT normal S2 split and S3 galop normal
559
Respiratory changes in preg
Diaphragm elevated 4cm 50mL O2/min (20% greater than normal) Dyspnea normal but should be evaluated
560
Hematologic changes in preg
Increase in plasma volume (50%) RBC, WBC, and coag factors increase Hgb should be monitored for anemia
561
Renal changes in preg
Kidneys dilate Serum Cr and BUN decrease Increase in urine freq from bladder compression Urinary incontinence common
562
GI changes in preg
Smooth muscle relaxation from progesterone decreases LES tone, decreased motility, adn impaired gallbladder contractility Increased gallstones and cholestasis of bile salts Hemorrhoids common Alk phos levels doubled from placenta Cholesterol increases
563
What causes morning sickness
Elevated progesterone, hCG, and relaxation of smooth muscle of stomach
564
Endocrine changes in preg
Euthyroid state Thyroid gland enlarges Reduced response to insulin (check for gestational diabetes 24-48 weeks)
565
MSK changes in preg
Relaxin and progesterone relaxes ligaments Pubic sympysis separates at 28-30 weeks Lumbar lordosis common in late preg Serum caclium decreases and PTH increases but no bone loss
566
Skin changes during preg
Spider angiomata Palmar erythema Striae gravidarum Hyperpigmentation Melasma Lower abdomen linea alba darkens to be come linea nigra
567
Reproductive changes in preg
Increased discharge (leukorrhea) Breasts get bigger
568
Where does oxygenation of fetal blood happen
Placenta Goes from placenta to umbilical vein that goes into portal system of fetus
569
Fetal circulation
Oxygenated blood flos into IVC then right atrium Flows across to left atrium through foramen of ovale Then goes into ascending aorta to rest of body Then enters right atrium and flows into right ventricle to bypass lungs and through ductus arteriosus into descendng aorta into umbilical arteries back to placenta
570
Common symptoms during preg
Headache (treat with tylenol) Edema NV (treat with ginger, bonjesta, or B6 and doxylamine) Heartburn (treat with tums)
571
When and how to screen for down syndrome, trisomy 18, and trisomy 13
First trimester NIPTs Nuchal transparency on ultrasound and hCG and preg-associated plasma protein A
572
Amniocentesis
Taking out 20-3mL of amniotic fluid transabdominally with US guidance to diagnostic for trisomies and neural tube defects after screening detects
573
How often do we see pregnant for antenatal visits
4 weeks until 28 weeks 2 weeks 28-36 weeks 1 week 36 weeks-delivery
574
Antenatal tests/procedures for 6-12 weeks
Confirm preg and uterine size Urine culture Pap smear for 21 or older screening for chlamydia and gonorrhea Random blood glucsose Blood group and Rh RPR, HPV, Hep B Rubella antibody Varicella immunity
575
Antenatal tests/procedures for 16-20 weeks
Fetal ultrasound Cervical length measurement Genetic testing
576
Antenatal tests/procedures 24-28 weeks
Gestational diabetes screening 1 hour 50 gram glucola test if >140 test fasting 3 hour 100gram glucola
577
Antenatal tests/procedures 28 weeks
Rh(d) immune globulin (Rhogam) if Rh negative Hgb or CBC for screening Determine fetal position and presentation Ask about movement
578
Antenatal tests/procedures 36 weeks
Group B strep screen (single culture from vagina and rectum) give penicillin INTRAPARTUM if positive unless urine culture positive, then treat now Begin cervical checks Discuss labor indicators
579
Antenatal tests/procedures 41 weeks
Cervical exam to see probability of induction Induction facorable if cervix >2cm, 50% effaced, certex and -1station, soft cervix, and midpositoin Do stress test if cervix not favorable
580
Antenatal tests/procedures 42 weeks
Induction performed no matter what
581
Goal BP for preg
<140/90
582
When is fundus of uterus at umbilicus
20 weeks
583
Normal fetal HR
110-160
584
Leoplold maneuvers
palpating to determine baby's position
585
Non-stress test
Evaluates HR in response to fetal activity You want HR to accelerate
586
Constraction stess test
Measures response of fetal HR to stress of uterine contraction We don't want HR to react, it shows baby can't compensate for increase of pressure
587
Biphysical profilse
Dne if nonstress test is positive to see prence of fetal movement and tone
588
Rupture of membranes
Water breaks Can be slow trickle or large gush Can happen before or during labor
589
What to note when water breaks
Time Color Odor Amount Fetal response
590
How to confirm rupture of membranes
pH >7 Pooling on speculum blade Fern test (poling fluid looked under microscopy)
591
Meconium
Thick, black, tarry substance Made of amniotic fluid, lanugo, bile, fetal skin, and intestinal cells Neonates "first stool"
592
First Stage of labor
Lasts 10-14 hours for first preg Onset of true contractions through complete dilation and effacement of cervix Regular contractions at first then irregular and slow dilation
593
Second stage of labor
Lasts 1-2 hours for first pregnancy From dilation and effacement and ends with delivery of baby
594
Third stage of labor
Lasts 5-15 mins starts with birth and ends with delivery of placenta
595
Episotomy
Cut the gooch to avoid bad tear
596
Three signs of placental separation
Uterus rises in abdomen becoming firm Gush of blood
597
Fourth stage of labor
First hour postpartum Perineal pads used to monitor blood loss Check BP and pulse
598
Contraindications of breastfeeding
Women with HIV Women with active untreated TB Chemo Glactosemia of infant Illegal drug use
599
Meds contraindicated in breastfeeding
Lithium carbonate Tetracycline Bromocriptine Methotrexate Any radioactive substance
600
Colostrum
Made first 5 days postpartum and slowly replaced by maternal milk Contains more mineral but less fat and sugar than maternaal milik Contains immunoglobulin A
601
Lochia
Discharge after delivery that can last several weeks 1. lochia rubra 2. lochia serosa 3. lochia alba
602
Lochia rubra
Menses like bleeding first few days post partum
603
Lochia serosa
Lighter discharge with less
604
Lochia alba
White discharge tat can occur for few weeks
605
Postpartum depression tretment
SSRI or TCA
606
Postpartum psychosis treatment
Inpatient hospitalization Mood stabilizer or atypical antipsychotic Psychotherapy
607
Date rape drug examples
Gamma hydroxybutyrate Rhoypnol (ruffies)
608
Paraphilia
Intense and persistent sexual interest other than genital stimulation
609
Voyeristic disorder
6 months Observing nonsuspecting person who is naked Acted on sexual urges or it bothers functionality Must be 18yo
610
Exhibitionistic disorder
6 months Arousal from exposing yourself to unsuspected person Acting on it or bothers functionality
611
Exhibitionistic disorder comorbidities
Antisocial history Antisocial personality disorder Pedophilic disorder Childhood abuse Alcohol use disorder Sexual preoccupation
612
Frotteuristic disorder
6 months Sexual arousal from rubbjng on nonconsenting person Acted on it or has caused distress
613
Frotteuristic disorder risk factor
ANtisocial behavior Sexual occupation
614
Transvestic disorder
6 months Sexual arousal from cross dressing Only during sexy time
615
Fetishistic disorder
6 months Arousal from nongenital body parts Causes distress/impairment
616
Sexual masochism disorders
6 months Sexual arousal from being humiliated, beaten, bound, or made to struffer Causes significant distress or impairment of functioning
617
Sexual sadism disorder
6 months Sexual arousal from sufering of another person Acted on with nonsenting person Causes significant distress or impairment of funciton
618
Ssexual masochism and sadism disorders risk factor
Porn showing these things
619
Pedophilic disorder
6 months Recurrent intense, arrousing fantasies of child (13 or younger) Acted on Person is at least 16 and 5 years older than child
620
pedophilia risk factors
Child porn Antisocial personality disorder Childhood sexual abuse
621
Paraphilic disorder treatment
FIRST LINE: Psychotherapy Alternative: SSRI Antiandrogen
622
Ectopic pregnancy treatment
Methotrexate stops the growth Surgery when mom unstable (salpingostomy or salpingestomy)
622
Spontaneous abortion
miscarriage Absence of any medical or surgical intervention
623
Threatened abortion
Patient is bleeding in early pregnancy without clear diagnosis of pregnancy loss
624
Inevitable abortion
Cannot be avoided bc cervix is open Heavy bleeding Abd cramping present
625
Incomplete abortion
Persistent pregnancy tissue in uterus after diagnosis of preg loss Cervix can be open or closed Some products have passed out of uterus and some is still there
626
Complete abortion
Pregnancy spontaneously passes all contents of uterus Cervix closed and empty
627
Missed abortion
Retnetion of failed intrauterine pregnancy for extended period
628
Recurrent pregnancy loss definitino
Three consecutive pregnancy losses
629
What to check woman with recurrrent preg loss for
Ashermans syndrome (hyesteroscopy shows scarring)
630
What normaly causes first trimester pregnancy loss
Genetic anomoly
631
What normally causes second trimester pregnancy loss
Anatomic abnormalities like uteri or fibroids. Cervical insufficiency
632
What mom needs Rh D immunoglobulin shots
Rh negative Bc will kill Rh positive baby
633
Placenta previa
Placenta location is close or over cervical OS
634
Placenta previa presentation
Painless bleeding
635
Placenta previa diagnostic studies
Transvaginal ultrasound
636
Placenta previa delivery
C section
637
Placenta previa risk factors
Previous CS, >35yo, multiparity, smoking
638
how to reduce risk of bleeding in placenta previa
No digital exam No avoid sexual activity that may lead to orgasm
639
Placental abruption
Premature separation of placenta from implantation site Bleeding in decidua basalis causes separation of placenta
640
Placental abruption presentation
Abd pain and bleeding Could be concealed (no blood coming out)
641
Placental abruption risk factors
Chronic HTN, preeclampsia, multuiple gestation, >35yo
642
Placental abruptino management
Watch vitals Fluids Delivery for severe hemorrhage
643
Which twin is bigger in multiple gestation
Recipient twin is bigger than donor twin
644
Hydatidiform mole
Molar preganncy Occurs when normal placental trophoblastic tissue is replaced by hydropic placental villi
645
Partial hydatidiform mole
Fertilization of normal ovum by two sperm Results in triploid HCG usually low
646
Complete hydatidiform mole cause
Sperm fertilizess blighted ovum (no DNA) HCG usually high causing hyperemesis
647
Molar pregnancy on ultrasound
Snow storm No fetal parts
648
Molar pregnancy presentation
Hyperemesis Size large for dates HTN Vaginal bleeding
649
Molar pregnancy treatment
Uteruine evacuation by dilation of cervix and suction currettage Monitor for 6-12 months Birth control to avoid preg for 12 months Rh negative need rhogam
650
Malignant gestational trophoblastic disease
HCGs never fall to 0 after pregnancy (normal or molar) Can be localized or metastatic
651
Types of malignant gestational trophoblastic disease
Invasive mole Choriocarciinoma
652
Malignant gestational trophoblastic diagnostic imaging
Pelvic ultrasound Xray
653
Malignant gestational trophoblastic disease treatment
Etoposide, methotrexate, actinomycin D, cyclophoamide, vincristine
654
Hyperemesis gravidarium
Most severe form of preg associate nausea and vomitting
655
Gestational diabetes pathophys
Pregnancy comes with insulin resistance Pancreatic function doesn't respond well to resistance
656
What BP in pregnant is concerning
>140
657
Gestational diabets management
Insulin GOLD Better diet Education about uncontrolled glucose
658
What size baby in gestational diabetes needs C section
>4500 grams
659
Preeclampsia
HTN with proteinuria after 20 weeks gestation and maybe end-organ dysfunction
660
Preeclampsia risk factors
Nulliparity Multifetal gestations >40yo Chronic HTN Nrphropathy and other renal disease Obesity African american In vitro fertilization
661
Diagnostic citeria for severe preeclampsia
BP > 160/110 on two occasions at least 4 hours apart Progressive renal insufficiency Cerebral of visual disturbances Pulmonary edema RUQ pain Hepatic dysfunction
662
Preeclampsia presentation
Persistant edema in upper extremities and sacral region Vasonstriction and retinal blood vessels
663
What to do for preeclampsia babies >34 weeks
Induce birth
664
Preeclampsia management
Magnesium sulfate to prevent eclamptic seizures
665
What meds to use for preeclampsia HTN
Labetalol Hdralazne Nifedipine Methyldopa
666
Eclampsia
Seizure activity in pregnancy without history of seizures Life threatening for mom and baby Can happen before, during, or after labor
667
HELLP syndrome
Hemolysis Elevated Liver functions Low Plateletes Type of preeclampsias
668
Fetal fibronectin
Cervicovaginal specimen that predicts if pt will deliver in next 7 days (not valid if had sex in past 48 hrs)
669
Preterm labor treatment
CCS for lung maturity Tocolytics (mag sulfate, beta-adrenergic terbutaline) to prolong pregnancy
670
When to admit preterm labor
Cervix dilated to 2cm before 34 weeks Contractions occur causing cervical change Rupture of membranes
671
Premature rupture of membrane diagonsis
pH > 7.1 Fern test (looks like fern on microscope)
672
Premature rupture of membranes treatment
Betamethasone for lungs Prophylactic abx (ampicillin, amoxicillin, azithromycin
673
Chorioamnionitis
Intraamniotic infection Give ampicillin and gentamicin
674
Umbilical cord prolapse treatment
STAT delivery via C section
675
Types of breech presentations
Frank (butt, most common) Incomplete (footling) Complete
676
Breech presentation diagnosis
Leopold's first maneuver Fetal heart tones in upper quadrant Vaginal exam doesn't show head Ultrasound confirms
677
What to do if baby is breech presentation
C section
678
Shoulder dystocia
Fetal shoulder behind symphysis pubis during vaginal delivery. Baby starts coming out then slides back in like a turtle More likely to happen in >4000g
679
Shoulder dystocia treatment
suprapubic pressure Mcroberts maneuver (legs to chest) Rubin's maneuver (Rotation or delivery of posterior arm) Gaskin's maneuver (mom on hands and knees)
680
What can be used in operative vaginal delivery
Forceps and vacuums
681
Number one cause of postpartum hemorrhage
Uterine atony
682
Postpartum hemorrhage management
Oxytocin infusion after delivery Uterine management