Haem - Bleeding Disorders

Question 1

Vascular defects, platelet disorders

Answer 1

Superficial
bleed skin, mucous mb

Immediate
bleed after injury

Question 2

Coagulation disorders

Answer 2

Deep tissues
bleed muscles joints

Delayed
but severe
Prolonged
bleed after injury

Question 3

Vascular defects (bleeding)

Congenital

Acquired

Answer 3

Congenital
osler-Weber-Rendu
(hereditary haemorrhagic telangiectasia)
connective tissude disease (Ehlers-Danlos)

Acquired
Senile purpura
infection (meningococcal, measles, dengue)
Steroids,
scurvy (perifollicular haemorrhages)

Question 4

Pl disorders
Decrease pl function

congenital

acquired

Answer 4

Congenital
storage pool disease (pl release granules therefore no longer function)
Thrombasthenia (glycoprotein deficiency)

Acquired
aspirin
cardiopulmonary bypass
uraemia

Question 5

Pl disorders
Thrombocytopenia (not 150-400x109g/l)

dec production

inc destruction

Answer 5

dec production
BM failure

Inc destruction
AITP (acute and chronic) i.e. ITP?
drugs - heparin, 
DIC, 
HUS, 
TTP