HCC

Question 1

What are the risk factors for HCC?

Answer 1

Older age - most common liver cancer beyond 10 y.o.

Any underlying liver diseases (hepB, genetic disorders, BA etc.)

Androgenic steroids

Question 2

Genetic associations with HCC?

Answer 2

Alagille
PFIC
Fanconi anemia
Glycogen storage disease*
NF-1

Question 3

Screening for HCC?

Answer 3

Only in known HBV infected children - serial AFP and ultrasound.

Question 4

Staging for HCC?

Answer 4

PRETEXT same is HB

Question 5

Work up and treatment of HCC?

Answer 5

labs: CBC, enzymes, function, AFP, CEA, Genetics for glycogen storage disease, tyrosine is, and Wilson’s

Imaging: MRI Liver, CT chest

Bx unless diagnosis certain

Treatment: Surgical resection is the only chance for long term survival. Pretext 1/2 should have resection. Non-resectable tumors should be referred for transplant.