Headache

Question 1

Familial Hemiplegic Migraine

Name the three types with associated genes and resultant channelopathies

Answer 1

1.    **FHM type1- Autosomal dominant**
   Chr 19 p13 (**CACNA1A gene**)- defect in P/Q calcium channel subunit
2.    **FHM type 2- Autosomal dominant**
   chromosome 1q23 (**ATP1A2 gene**)  defect in the A1A2 sodium-potassium ATPase channel
3.    **FHM type 3- Autosomal dominant**
    Chromosome 2 q 24 (**SCN 1 A gene**) defect in presynaptic & postsynaptic voltage gated sodium channel