Headache pathophysiology Flashcards

(26 cards)

1
Q

Differentiate between primary headache and secondary headache
Examples

A

Primary
- no causative disorder
Ex. TTH, migraine, cluster

Secondary
- caused by another disorder close by
- Ex. Head/neck, non-vascular, infection,
psychiatric

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2
Q

T/F Chronic daily headache can only result from a secondary headache

A

False
- both

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3
Q

TTH
Location
Quality
Intensity
Duration
Photophobia/phonophobia (light/sound)
Pain worsen with movement?
Nausea?

A

Location
- bilateral

Quality
- pressing or tightening

Intensity
- mild to moderate

Duration
- minutes to days

Photophobia/phonophobia (light/sound)
- may be present

Pain worsen with movement?
- DOES NOT WORSEN with physical activity, movement

Nausea?
- NOT present

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4
Q

What characteristics do all TTH have to have? (4)

A

2 of the following

  1. Bilateral location
  2. Pressing or tightening (non-pulsating)
  3. Mild-mod intensity
  4. Not aggravated by routine physical activity
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5
Q

Diagnose infrequent episodic TTH
How many headaches/month/year

A

<1day/month
<12/year

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6
Q

Diagnose frequent episodic TTH
How many headaches/month/year

A

1-14 days/month for 3+ months
Less than 180 days/year

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7
Q

Diagnose chronic TTH
How many headaches/month/year

A

15+ days/months for 3+ months
More than 180 days/year

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8
Q

How long do infrequent/frequent (episodic) TTH headaches last?
Chronic?

A

Lasting 30 min - 7 days

Chronic
- hours to days
- unremitting

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9
Q

What do all infrequent/frequent episodic TTH headaches have to have? (2)
Chronic? (2)

A

Episodic
- No N/V
- No more than 1 of: photophobia or phonophobia

Chronic
- No more than 1 of: photophobia or phonophobia or nausea
- No mod-severe N/V

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10
Q

Migraine
Location
Quality
Intensity
Duration
Photophobia/phonophobia (light/sound)
Pain worsen with movement?
Nausea?

A

Location
- Unilateral

Quality
- Throbbing, pulsating

Intensity
- 4 phases to migraines (moderate to severe)
- prodrome, +/- aura, headache, postdrome

Duration
- 4-72 hours

Photophobia/phonophobia (light/sound)
- Yes
- osmophobia

Pain worsen with movement?
- Aggravated by movement

Nausea?
- N/V

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11
Q

Symptoms of prodrome migraine?
When does it happen

A

24-48 hrs

Tired, drowsy, yawning
Food cravings & thirst
More urination
Diarrhea or constipation
Stiff neck
Anxiety, depression
Euphoria, irritability

*May start to experience sensitivity to light, sound & smell

*Like a yellow light/warning phase for early treatment

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12
Q

Aura symptoms
Duration
Positive
Negative

A

Duration
- 5-60 min

Positive
active discharge from CNS neurons)
- Often VISUAL: bright lines, shapes, objects
- Auditory: tinnitus, noises, music
- Somatosensory: burning, pain, paresthesia
- Motor: jerking or repetitive rhythmic movements

Negative
absence or loss of function
- Loss of vision, hearing, feeling, ability to move a body part

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13
Q

of attacks

What is the diagnostic criteria for migraine without aura
# of attacks
Duration
Characteristics (4)
Phobias/nasuea

A

At least 5 attacks fulfilling:

Duration
- Headache attack lasts 4-72 hours (with or without treatment)

Headache has at least 2 of the following:
1. Unilateral
2. Pulsating
3. Moderate-severe pain intensity
4. Aggravated by physical activity

Headache has at least 1 of the following:
1. Nausea and/or vomiting
2. Photophobia and phonophobia

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14
Q

of attacks

What is the diagnostic criteria for migraine WITH aura
Duration
Symptoms (6)
Characteristics (6 sections)

A

At least 2 attacks fulfilling:

Headache has at least 1 of:
1. Visual
2. Sensory
3. Speech and/or language
4. Motor
5. Brainstem
6. Retinal

Headache has at least 3 of:
1. At least 1 aura sx spreads gradually over 5 or more minutes
2. 2 or more aura sx occur in succession
3. Each individual aura sx lasts 5-60 mins
4. At least 1 aura sx is unilateral
5. At least 1 aura sx is positive
6. The aura is accompanied, or followed within 60 mins, by headache

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15
Q

Chronic migraine
Days per month

A

15+days/month for 3+ months

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16
Q

Triggers for migraines (6)

A

Stress

Environmental
- Glare, bright or flickering lights
- strong odours, loud noise,
- weather changes, high altitude, tobacco

Dietary
- Alcohol, tyramine containing foods
- citrus fruits, chocolate, coffee

Menstrual cycle

Sleep
- Sleep disturbances, fatigue, fasting/dieting, strenuous exercise

Meds:
- Nitric oxide, PDEi, alcohol, cocaine, histamine, CGRP

17
Q

Risk factors for chronic migraine (11)

A
  • Female sex
  • Family history
  • High baseline attack frequency (>1/week)
  • Inadequate acute treatment of migraine attacks
  • Overuse of acute medications
  • Caffeine consumption
  • Obesity
  • Allodynia (normal touch becomes painful)
  • Head injury
  • Low socioeconomic status
  • Comorbid conditions (Neurological, CV, MSK, SA)
18
Q

Cluster headache
Location
Quality
Intensity
Duration
Features
Pain worsen with movement?

A

Location
- unilateral
- one orbit

Quality
- EXCRUCIATING, penetrating

Intensity
- Severe,
- suicide HA, hot poker, stabbing, alarm clock

Duration
- 15min - 3h
- USUALLY AT NIGHT around spring/fall

Features
- conjunctival features (tearing, lacrimation, nasal)
-

Pain worsen with movement?
- Movement required to manage headache

19
Q

of attacks

Cluster headache diagnostic criteria
#of attacks
Characteristics (4)
Features (7)
Frequency

A

At least 5 attacks:
- Severe unilateral
- supra-orbital
- temporal pain
- Occurs at the same time each day - usually at night

Features
At least one of:
- Conjunctival injection and/or lacrimation
- Nasal congestion and/or rhinorrhea
- Forehead and facial swelling
- Miosis, ptosis, eyelid edema, sense of restlessness (pacing, rocking, holding the head)

Frequency: 1 every other day to 8 per day
- 1-2 attacks per year
- can have remissions of months

20
Q

What are cluster headaches precipitated by (5)

A
  • Alcohol
  • Naps
  • Stress
  • MISSED meals
  • Vasodilating drugs
21
Q

What is chronic daily headache defined as
days/month

A

15+ days/month for 3+ months

22
Q

of days of drug use

MOH
Location
Quality
Intensity
Duration

A

Location
- uni or bilateral

Quality
- depends on medication
Triptan: migraine like attacks
Triptan + analgesic: Continuous HA

Intensity
- mild-mod

Duration
- Depends

Drug use
- Triptans, Egos, opioids = 10+ days
- Acetaminophen/NSAID/non-opioid analgesics = 15 days+

23
Q

Diagnostic criteria for MOH (2)

A

Headaches occurs on 15+ days/month in patient WITH pre-existing headache disorder

Regular overuse for 3+ months of 1+ drug that can be taken for acute and/or symptomatic treatment for headache

24
Q

Pathophysiology of TTH

A

Peripheral activation or sensitization of myofascial nociceptors (central)

Central
- inc general pain sensitivity in CNS

Peripheral
- myofascial trigger points
- inflammation

25
Pathophysiology of migraine
Pain in the CN V - the trigeminal nerve Triggered by 1. cortical spreading depression --> wave of neuronal depolarization --> 2. which activates trigeminal afferents --> releases CGRP (a peptide 3. Causes dysregulation of brainstem nuclei ***No peripheral involvement
26
Pathophysiology of cluster headache
Not completely understood. Most plausible theory: hypothalamus begins the attack Vascular theory: Inflammation damages trigeminal nerves - Genetics