Hematological Focus Flashcards

(36 cards)

1
Q

What does the white pulp do in the spleen

A

storage of white blood cells and antibody production

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2
Q

what does the red pulp do in the spleen

A

storage of RBCs and platelet

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3
Q

what is the spleen function

A

regulates RBCs production, destroys old/imperfect RBCs, filters out bacteria

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4
Q

what does the liver store

A

stores extra whole blood cells and ferritin

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5
Q

what vitamin does the liver also produce

A

vitamin K

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6
Q

what do platelets do

A

sticks to injury site and form clot

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7
Q

How is hemostasis balanced

A

with anticoagulants

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8
Q

what does the coombs test detect

A

antibodies that act against hemoglobin

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9
Q

what are some ss of sickle cell

A

pain and joint swelling + anemia ss: fatigue, weakness, pallor, SOB, increased HR, cold hands and feet

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10
Q

what does SICKLE stand for

A

significant blood loss, illness/injury, climbing to high places, keeping continued stress, low fluid intake, extreme temp changes

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11
Q

what is aplastic anemia

A

bone marrow cant keep up with RBC production

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12
Q

what are some preventative measures for sickle cell

A

vaccines, dont go to high altitudes, prevent infection, dont smoke, decrease stress, avoid overexcertion

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13
Q

what does the hemoglobin electrophoresis test

A

different types of hemoglobin

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14
Q

what does the medication Hydroxyurea treat

A

sickle cell and some cancers

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15
Q

how does hydroxyurea work and what does it help with

A

creates fetal hemoglobin and decreases WBC, so less sickling, decreased need for blood transfusions, helps anemia,

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16
Q

where is most of the bodys iron found

A

70% in hemoglobin

17
Q

what does LOW IRON stand for

A

lethargy, overexerted easily, weird food cravings/white face, inflamed tongue/increased HR, reduced hemoglobin, observable RBC changes, nail changes (spoon-shaped)

18
Q

what lab test evaluate iron levels

A

CBC, iron, blood smear

19
Q

what could be some causes for iron defecient anemia

A

poor intake, absorption problems (celiac disease, short gut syndrome, cycstic fibrosis), losing iron because of bleeding

20
Q

what are some ss of pernicious anemia

A

anemia symptoms: fatigue, pale, + red swollen tongue, confusion, depression, loss of appetite, unsteady gate, SOB with activity

21
Q

what is the treatment for thrombocytopenia

A

platelet transfusion, splenectomy, anticoagulants

22
Q

what is hemophilia

A

blood not clotting properly -> excess bleeding after an injury

23
Q

what is the treatment for DIC

A

Supportive care, fluids, blood transfusions

24
Q

what is factor V leiden

A

mutation of factor V cause and increase in clots

25
what is the treatment for factor V ledien
infusion of FFP, blood, and platelets
26
what is von willenbrand disease
bleeding disorder caused by decrease clotting
27
what is desmopressin used for treatment in
von willenbrand disease
28
what are some ss of nonhodgkins/ hodgkins lymphoma
large painless lymph nodes, fever, drenching night sweats, unplanned weight loss, some have none at time of diagnosis
29
what is the treatment of non-hodgkins/ hodgkins lymphoma
external radiation of lymph node areas, for more extensive: radiation + chemo, or CART-therapy
30
what are is the treatment multiple myeloma
watchful waiting, proteasome inhibitors, immunomodulating drugs, HSCT
31
what are the risk factors for leukemia
ionizing radiation, viral infection, exposure to chemicals and drugs
32
what is normal INR
0.75-1.25
33
what is the therapeutic INR range for warfarin
2-3
34
what is warfarins antidote
vitamin K
35
how does heparin work
activates antithrombin which inactivates thrombin and factor xa -> stopping fibrin
36
what is heparins antidote
protamine