Erythropoietin is a ____ that ____
Glycoprotein hormone, stimulates red blood cell production in response to low partial pressure of oxygen
Anemia
blood does not carry enough O2
Sickle cell anemia causes
rigid and sticky moon shaped RBC’s
Typical RBC live for
120 days
Sickle cells live for
10-20 days
Symptoms of sickle cell anemia are
Fatigue (from anemia)
Paine crises
Swelling
Frequent Infections
Disease of fusion of BCR and ABL genes on chromosome 22
Chronic Myeloid Leukemia
Leukemia cells from Chronic myeloid leukemia arise from
bone marrow
What is the philadelphia chromosme
BCR-ABL1 gene formed when pieces of chromosome 9 and 22 break off and trade places
Hematopoiesis occurs in
bone marrow