Hemostasis

Question 1

4 steps of hemostasis

Answer 1

1) vascular spasm
2) platelet plug
3) coagulation
4) repair of damage

Question 2

3 roles of thrombin

Answer 2

1) activate downstream components of coagulation cascade
2) upstream positive feedback (itself – propagation, VIII and V)
3) paracrine activity which influences hemostasis

Question 3

Thrombin can cause endothelial cells to release

Answer 3

NO
prostacyclins (PGI2)
tPA
ADP
vWF