Hepatitis differentials

Question 1

route of transmission

Answer 1

Question 2

which hepatitis is acquired through the faecal oral route

Answer 2

Vowels (A and E) are transmitted via the bowels (fecal-oral) and usually only cause AcutE hepatitis.

Question 3

clinical course of HDV

Answer 3

HBV required for HDV entry into hepatocytes
Acute coinfection with HBV usually leads to severe acute hepatitis.
HDV superinfection in patients with chronic hepatitis B increases the risk of liver cirrhosis and HCC.
More than 80% of patients with superinfection progress to chronic HDV infection.

Question 4

how is HEV transmitted

Answer 4

Fecal-oral
Parenteral
Perinatal

Question 5

clinical course of HEV

Answer 5

Asymptomatic
Similar to HAV, but milder
Increased risk of acute liver failure in pregnant individuals
In the majority of cases, the disease is self-limited.
Symptoms resolve after 2–4 weeks.

Question 6

is there a vaccine for HDV or HEV

Answer 6

no