1
Q
What is the MOA of INF-a drugs for HBV?
A
Inhibit viral DNA integration into host DNA via ZAP
2
Q
What is the MOA of Nucleoside/nucleotide drugs?
A
Inhibit reverse transcriptase and DNA polymerase from the virus
3
Q
Which drug would you use for HBV first line that is easy on the kidney?
A
Entecavir
4
Q
Which drug would you use for wild-type HBV first line that causes proximal renal tubule disease?
A
Tenofovir
5
Q
Which HCV drug inhibits NS5B?
A
Sofosbuvir
6
Q
Which HCV drugs inhibits NS5A?
A
Ledipasvir, Elbasvir, Velpatasvir
7
Q
What is the Genotype 1 drug regimen for HCV Tx?
A
Ledipasvir + Sofosbuvir
8
Q
What are the Genotype 2 drug regimens for HCV Tx?
A
Velpatasvir + Sofosbuvir
Elbasvir + Grazoprevir
Zak, GI 2
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