Hepatotoxicity

Question 1

What percentage of Caucasians are slow acetylators?

Answer 1

50%

Question 2

Erythromycin estolate is associated with hepaticellular necrosis

Answer 2

F

Cholestasis

Question 3

Cyp P450 enzymes produce only a small increase in hydrophilicity of drugs metabolized

Answer 3

T

They are phase 1 enzymes and largely oxidate i.e. add hydroxyl group

Question 4

% Caucasians with no 2D6 activity

Answer 4

10%