HF MoA

Question 1

nesiritide

Answer 1

structurally identical to BNP (hormone secreted by heart)

Question 2

beta-adrenergic antagonists

Answer 2

block high levels of catecholamine in HF pts
-slows cardiac remodeling

Question 3

digoxin

Answer 3

inhibits Na-K-ATPase
-sodium accumulates in myocytes
-calcium released from intracellular storage
-increased forceful contraction

Question 4

dobutamide

Answer 4

increased contractility w/o increasing HR and BP