Hist for Path: 2

Question 1

What do afferent arterioles arise from?

Answer 1

Interlobular arteries

Question 2

What do efferent arterioles arise from?

Answer 2

Glomerular capillaries

Question 3

What is mesangial matrix?

Answer 3

• Area in glomeruli between capillaries that holds them together

Question 4

What is name of smooth muscle in glomeruli that regulates blood flow and filtration?

Answer 4

• Mesangium

Question 5

3 functions of mesangium?

Answer 5

1. Contraction to regulate flow: smooth muscle cell
2. Structural support
   3 Phagocytosis

Question 6

Where are the fenestrations found?

Answer 6

• Cell walls of endothelial cells

Question 7

What does basement membrane divide?

Answer 7

Endocapillary: mesangial
Extracapillary: Urinary space

Question 8

What is in visceral epithelium?

Answer 8

Podocytes

Question 9

What is in between foot processes of epithelium?

Answer 9

Slit diaphragm

Question 10

What is the glomerular filtration barrier?

Answer 10

“Glomerular basement membrane” made of:

1. Basal lamina of endothelial
2. Podocytes

Question 11

What does glomerular membrane prevent from filtering?

Answer 11

1. Large molecules: Proteins

2. Negative molecules: albumin

Question 12

What is immunofluorescence used to detect?

Answer 12

1. Complement

2. Immunoglobulins

Question 13

Components of the nephron?

Answer 13

1. Glomeruli
2. Prox tubule
3. Loop
4. Distal

Question 14

Where does the distal tubule pass?

Answer 14

Near the glomerulus

Question 15

Which tubules have wider lumen?

Answer 15

Distal

Question 16

What structures are not found in medulla?

Answer 16

1. Glomeruli
2. Proximal tubule
3. Distal tubule

Question 17

What is found in medulla?

Answer 17

1. Loop of henle

2. Collecting ducts

Question 18

What is found on surface of proximal tubule?

Answer 18

• Brush border greatly increasing resorptive ability

Question 19

What is the macula densa?

Answer 19

• Region of distal tubule that runs by glomerulus

Question 20

What is the JG apparatus?

Answer 20

• Formed by distal tubule and afferent arteriole
• Regulates BP and filtration rate
• Regulates based upon distal [] of NaCl

Question 21

What is loss of glomerular slit diaphragms and appearance of a continuous layer of podocyte cytoplasm indicative of?

Answer 21

MCD

Question 22

What happens in MCD?

Answer 22

Loss of glomerular slit diaphragms and appearance of continuous layer of podocyte cytoplasm