HIV

Question 1

HIV prophylaxis

Answer 1

CD4 count determines need for ppx

<200 = bactrim or dapsone+ , or atovaqune (DC after cells 200+x3 months and remain on art; pjp ppx)

<100 = same as above (ppx toxoplasma)

<50 Azithro 1200 weekly (MAC ppx) d/c if takin fully supressive ART

Question 2

Maraviroc moa

Answer 2

ccr5 antagonist (binding/attachment)

Question 3

fostemsavir MOA

Answer 3

attachment inhibitor

Question 4

ibalizumab uiyk moa

Answer 4

post-attachment inhibitor

Question 5

NRTI/NNRTI MOA

Answer 5

reverse transcription

Question 6

lenacapvir MOA

Answer 6

capsid inhibitor, prevent nuclear import
Assembly inhibito
budding/maturation

Question 7

INSTI MOA

Answer 7

prevents integration (insertion of DNA into host cell)

Question 8

Protease inhibitors

Answer 8

prevent budding and maturation

Question 9

Pref initial ART

Answer 9

Biktarvy
Triumeq (5701)
Dovato (<500k)

Tivicay/Truvada (TDF)
Tivicay/Descovy (TAF)

Question 10

Biktarvy

Answer 10

Bictegravir (INSTI)
Emtricitabine/TAF (NRTI x 2)

Question 11

Triumeq

Answer 11

Dolutegravir (INSTI)
Abacavir/ Emtricitabine (NRTI x2)

Question 12

Dovato

Answer 12

Dolutegravir (INSTI)
Emtricitabine (NRTI)
complete only if viral load <500k due to only 1 NRTI

Question 13

Tivicay

Answer 13

Dolutegravir (INSTI)

Question 14

Truvada

Answer 14

Emtricitabine/TAF (NRTI x 2 )

Question 15

Descovy

Answer 15

Emtricitabine/TDF (NRTIx2)

Question 16

Genvoya

Answer 16

Elvitegravir (INSTI)
Cobicistat (booster)
emtricitabine/TAF (NRTI x 2)

Question 17

Striibild

Answer 17

same as genvoya but with TDF

Question 18

Epzicom

Answer 18

abacavir (NRTI)
lamivudine (NRTI)

Question 19

Cabenuva

Answer 19

cabotegravir (INSTI)
rilpiverine (NNRTI)

Question 20

Rilpiverine

Answer 20

NEED ACID to absorb

Question 21

Efavirenz

Answer 21

AVOID Food, too much absorb side effect CNS (QHS empty stomach)

Question 22

Drugs with rilpiverine

Answer 22

cabenuva
juuluca
complera
odefsey

Question 23

PREP

Answer 23

Truvada (3TC/TDF)
or
Descovy (3TC/TAF)
or
IM cabotegravir

Question 24

Apretude

Answer 24

IM cabotegravir

Question 25

Tybost

Answer 25

cobicistat 150mg with food w boosted drug 3a4 inhibitor

Question 26

Norvir

Answer 26

ritonavir 100-200 qd/bid with food w boosted drug (PI)

Question 27

NRTI

Answer 27

abacavir emtricitabine lamivudine tdf/taf zidovudine

Question 28

retrovir

Answer 28

zidovudine gv iv labor if preg

Question 29

INsTI

Answer 29

bictegravir cabotegravir dolutegravir eltegravir raltegravir

Question 30

NNRTI

Answer 30

efavorenz rilpiverine doravirine etravirinePI

Question 31

PI

Answer 31

aztanavir darunavir

Question 32

pi adr

Answer 32

high bg, lipid, insulin resistance, hep dysfx sjs/ten abdominal fat

Question 33

sulfa adr

Answer 33

darunavir fosfamprenavir tiprnavir

Question 34

aztanavir adr

Answer 34

bananavir hyperbili reversable separate antacid ppi separate, onlu use if boosted

Question 35

PEP

Answer 35

start in 72 hr; take for 4 weeks TRUVADA + tivicay OR Isentress (raltegravir) truvada if crcl >60