HLA

Question 1

Class 1 HLA

Answer 1

• A, B, C
• All nucleated cells
• Density varies from tissue to tissue

Question 2

Class 2 HLA

Answer 2

• DR, DQ, DP
• APCs
• B lymphocytes
• Activated T lymphocytes

Question 3

Most common caucasian HLA allele

Answer 3

HLA-A2

Question 4

Normal role of HLA molecules

Answer 4

Present pathogen derived peptides to the immune system

Question 5

Mismatched HLA molecules

Answer 5

Become the target of host immune response in transplant setting (rejection)

Question 6

Evidence that allograft rejection is immunologically mediated

Answer 6

• Latent Period
• Memory (2nd Set Rejection)
• Specificity
• Passive Transfer by lymphocytes
• Production of Antibodies

Question 7

Hyperacute rejection

Answer 7

• Preformed cytotoxic antibodies to donor antigens (or due to mismatched HLA)
• Complement activation, endothelial damage, inflammation, thrombosis

Question 8

Acute rejection

Answer 8

Development of allogenic reaction to donor antigens

Question 9

Chronic rejection

Answer 9

Multiple immune and non immune related factors (reversible

Question 10

Immunopathological reaction

Answer 10

Recurrence of original disease

Question 11

Recipient O

Answer 11

Donor O

Question 12

Recipient B

Answer 12

Donor B or O

Question 13

Recipient A

Answer 13

Donor A or O

Question 14

Recipient AB

Answer 14

A, B, AB, or O

Question 15

Mechanism of renal allograft chronic rejection

Answer 15

• Chronic endothelial damage and endothelial proliferation
• Ongoing cellular and vascular rejection
• Immune complex deposition
• Recurrence of original disease