HLA Compatibility Testing

Question 1

Hematopoietic Stem Cell Transplant (HCT)

Answer 1

entire immune system is transferred; recipient is totally immunodeficient for a period of time

Question 2

autologous transplant

Answer 2

patients own stem/progenitor cells harvested & returned
can be used if malignancy is not genetic
patient must have sufficient CD34+ cells

Question 3

allogeneic transplant

Answer 3

patients own immune system is destroyed & replaced with stem cells of another person
matches from siblings are ideal

Question 4

origin of anti-HLA antibodies

Answer 4

transfusions
pregnancies
previous transplants

Question 5

anti-HLA antibodies are what class?

Answer 5

all are IgG not IgM