Immunology > HLA System > Flashcards

HLA System Flashcards

(48 cards)

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1
Q

What is HLA?

A

Human Leukocyte Antigen

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2
Q

Chromosome and region for HLA

A

Chromosome 6 (short arm, p)

Region: MHC (Major histocompatibility complex)

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3
Q

What are the HLA class I antigens?

A

HLA A, B, C

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4
Q

Which cells do express class-I HLA?

A

Most cells

(in a form of house-keeping)

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5
Q

Which cells do not express class-I HLA?

A

RBC (Red blood cells) and Trophoblasts

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6
Q

Which immune cells do recognise the expression of class-I HLA?

A

CD8+ cytotoxic T cells

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7
Q

What are the HLA class II antigens?

A

HLA >> DP, DQ, DR

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8
Q

Which cells do express class-II HLA?

A

Professional APCs (Antigen-presenting cells)

(These are the cells of innate immunity that (spend their days) >>> to phagocytose extracellular materials >>> antigen expression)

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9
Q

Which immune cells do recognise class II HLA?

A

CD4 T lymphocytes

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10
Q

Which class of HLA is particularly important to match in transplantation?

A

HLA class II: DP, DQ. DR

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11
Q

Relation of HLA-Ds & HLA-Bs with antibody

A

HLA- Ds (DP, DQ, DR) correspond to diseases which have antibody tests

HLA Bs (B27, B5, B47 etc.) correspond to diseases which have NO detectable antibodies

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12
Q

HLA-A3 >>> Diseases

A

Haemochromatosis

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13
Q

HLA-B1502 >>> Diseases

A

Steven Johnson syndrome

(in response to carbamazeine use in Han Chinese population)

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14
Q

HLA-B5 >>> Diseases

A

Behcet’s disease

(HLA B51 is a split of B5; MICA allele)

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15
Q

HLA-B27 >>> Diseases

A
  • Seronegative spondyloarthropathies
    • Ankylosing spondylitis
    • Reiter’s syndrome (including. Reactive arthritis)
    • Psoariatic arthritis
    • Enteropathic arthritis (Associated with IBD)
  • Post-gonococcal arthritis
  • Acute anterior uveitis
  • Whipple’s disease
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16
Q

HLA-B35 >>> Diseases

A

Subacute thyroiditis

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17
Q

HLA- B47 >>> Disease

A

21-hydroxylase deficiency

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18
Q

HLA-DR2 >>> Diseases

A
  • Nacrolepsy
  • Goodpasture’s syndrome
  • Multiple sclerosis
  • SLE (less common)
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19
Q

HLA-DR3 >>> Diseases

A
  • Autoimmune hepatitis
  • Primary billiary cirrhosis (PBC) (Also DR8)
  • Primary Sjogren’s syndrome (PSS)
  • Diabetes mellitus type I
  • Dermatitis herpetiformis
  • Coeliac disease (95% associated with HLA DQ2, 80% with B8)
  • SLE (Systemic Lupus Erythematosus)
  • Addison’s disease
  • Membranous GN
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20
Q

HLA-DR4 >>> Diseases

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A

Rheumatoid arthritis

Diabetes mellitus type I

Pemphigus

Drug induced lupus erythematosus

IgA nephropathy

PMR (Polymyalgia Rheumatica)

21
Q

HLA-DR8 >>> Diseases

Study These Flashcards
A

Primary billiary cirrhosis (PBC) (Also DR3)

22
Q

HLA DR3 + DR4 combined >>> Diseases

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A

Diabetes mellitus type I

23
Q

SLE >>> HLA

Study These Flashcards
A
  • HLA A1
  • HLA B8
  • HLA DR2
  • HLA DR3
24
Q

Coeliac disease >>> HLA

Study These Flashcards
A
  • HLA-DQ2 (95%)
  • HLA-DQ8
  • HLA-B8 (80%)
  • HLA-DR3
25
**Diabetes mellitus type I \>\>\> HLA**
* **HLA DR4 (mainly)** * **HLA DR3**
26
**Psoriasis \>\>\> HLA**
**HLA-cw6**
27
**Felty's syndrome: Dx triad**
* **Rheumatoid arthritis** * **Splenomegaly** * **Neutropaenia**
28
**Felty's syndrome \>\>\> HLA**
**HLA DR4 (90%, strongly associated)**
29
**Seronegative spondyloarthropathies** * **Ankylosing spondylitis** * **Reiter's syndrome (including. Reactive arthritis)** * **Psoariatic arthritis** * **Enteropathic arthritis (Associated with IBD)** **\>\>\> HLA ??**
**HLA B27** (All have the same HLA)
30
**Post-gonococcal arthritis \>\>\> HLA**
**HLA B27**
31
**Acute anterior uveitis \>\>\> HLA**
**HLA B27**
32
**Whipple's disease \>\>\> HLA**
**HLA B27**
33
**Narcolepsy \>\>\> HLA**
**HLA- DR2**
34
**Goodpasture's syndrome \>\>\> HLA**
**HLA DR2**
35
**Multiple sclerosis \>\>\> HLA**
**HLA DR2**
36
**Autoimmune hepatitis \>\>\> HLA**
**HLA DR3**
37
**Primary billiary cirrhosis (PBC) \>\>\> HLA**
**HLA DR3** **HLA DR8**
38
**Primary Sjogren's syndrome (PSS) \>\>\> HLA**
**HLA DR3**
39
**Dermatitis herpetiformis \>\>\> HLA**
**HLA DR3**
40
**Addison's disease \>\>\> HLA**
**HLA DR3**
41
**Rheumatoid arthritis \>\>\> HLA**
**HLA DR4**
42
**21-hydroxylase deficiency \>\>\> HLA**
**HLA B47**
43
**Haemochromatosis \>\>\> HLA**
**HLA A3**
44
Behcet's disease \>\>\> HLA
**HLA B5** **(HLA B51 is a split of B5; MICA allele)**
45
**Subacute thyroiditis \>\>\> HLA**
**HLA B35**
46
**Abacavir hypersensitivity (a Tx of HIV) \>\>\> HLA**
**HLA B\*57:01**
47
**Steven Johnson syndrome** **(in response to carbamazeine use in Han Chinese population)** **\>\>\> HLA**
48
**HLA B\*57:01 \>\>\> Disease**
**Hypersensitivity to Abacavir (an HIV treatment)**
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