What three things cause release of gastrin from the G cells?
vagal stimulation, distention and digested protien
two cellular targets for gastrin?
parietal cells and enterochromaffin-like cells (ECL) cells
what cells other than g cells produce gastrin?
pancreatic endocrine cells, pituitary and extraantral G cells
What hormone is implicated in the devlopment of GI cancers?
gastrin
what hormone is considered a key growth regulator in the gut mucosa?
gastrin
what are the two active forms of gastrin?
G-17 and G-34
what type of gastrin is in circulation during fasting and why?
G-34 because G-17 is cleared from circulation faster
what form of gastrin is released after a meal?
G-17
what do small peptides, aromatic amino acids and calcium stimulate release of?
gastrin
what negatively regulated gastrin release?
decreased pH levels following acid secretion.
what does CCK stand for?
cholecystokinin
where is CKK produced?
endocrine cells located in the proximal small intestine?
Role of CKK
gallbladder contraction an pancreatic enzyme secretion
effect of CKK on physiological functions
inhibition of gastric emptying stimulation of bowel motility, potentiation of insulin secretion
