HPV

Question 1

HPV structure & classification

Answer 1

Family: Papillomaviridae
Genus: Papilomavirus

dsDNA NON enveloped

Baltimore: I

> 200 types

Question 2

Medically important HPV

Answer 2

1. Cutaneous warts - 1,2,3,4,7,10
2. Anogenital - condyloma acuminata - 6,11,16
3. Cervical Ca & penile Ca - 16 & 18

Question 3

HPV diagnostic staining

Answer 3

p16 & ki-67 stains

Question 4

HPV natural history

Answer 4

70% clear in year 1
90% by year 2

Persistent infections by problematic type leads to warts/cancer - 16&18

Question 5

HPV vaccine

Answer 5

Sub-unit vaccine with major protein of capsid

UK - Gardasil 9 : 6,11,16,18,31,33,45,52,58

Regimens by JCVI:

1. one dose for adoloscents
2. One dose for GBMSM < 25 years
3. Two doses for GBMSM 25-45 years
4. Three doses for HIV/immunosuppression < 25 years or <45 if GBMSM

TWO doses if > 25 years @ 0,2 years

Question 6

HPV receptor & oncogene

Answer 6

Receptor: HSPG
Gene: E 6/7