Hyper Aldosteronism

Question 1

Primary HyperAldosteronism - Causes - 4

Answer 1

1. Bilateral idiopathic hyperplasia - 60%
2. Adenomas - 35%
3. Conn’s syndrome - more in woman
4. CYP11B1 and aldosterone synthase fuse, and cells secrete aldosteron in response to ACTH - can be managed with steroids to lower ACTH.

Question 2

Primary HyperAldosteronism - Effects - 2

Answer 2

Higher BP

Hypokalemia

Question 3

Adenomas - Morphology - 5

Answer 3

Less then 2 cm
Usually on the left side
Yellow
Cells are filled with fat
If treated with spironolactone can see spironolactone bodies - pink thingy.

Question 4

Bilateral idiopathic hyperplasia - Effects

Answer 4

Causes 5-10% of secondary high BP, 20% are resistant to treatment.

Question 5

Primary HyperAldosteronism - Treatment - 2

Answer 5

Adenoma - spironolactone and surgery

Bilateral idiopathic hyperplasia - spironolactone only

Question 6

secondary HyperAldosteronism - Renin is high - Causes - 5

Answer 6

1. Renal artery stenosis
2. Hypovolemia
3. Chirosis
4. Nephrotic syndrome
5. Pregnancy