Hyperandrogenism

Question 1

List the clinical presentation of hyperandrogenism

Answer 1

Acne
Hirsutism -male pattern balding
Virilisation- Deepen voice

Question 2

List the causes of hyperandrogenisms

Answer 2

Increased production:
1. Ovarian
-PCOS
-Androgen producing tumours

2. Adrenal
   -CAH
   -Adrenal tumours
3. Increase peripheral production
   -Obesity
4. Decreased plasma binding
   -obesity
   -hyperinsulemia
5. Exogenous intake
   -Medication eg testosterone

Question 3

Discuss treatment of hyperandrogenisms

Answer 3

Non pharmacological:
-weight loss
-exercise
-healthy diet

Pharmacological
-Corticosteroids
-Combined OC
-Spironolactone (binds androgen receptor)
-GnRH agonist
-Metformin

Question 4

What is the timeline for therapeutic response in hyperandrogenisms

Answer 4

Acne -6 weeks
Facial hair/ hursuitism-6months