Hypercoagulable states

Question 1

• Most common hereditary coagulation disorder in US
• Almost exclusively in whites
• Gene mutation of Factor V prevents protein C from binding, and thus from its inhibition of the factor

Answer 1

• Factor V Leiden

- (Activated protein C resistance)

Question 2

• Antibodies predispose pt to thormbosis
• Autoimmune disorder
• Life long coagulation

Answer 2

Antiphospholipid antibody syndrome

Question 3

Deficiency results in less inhibition of clotting factor, and unrestricted clot formation

Answer 3

Protein C deficiency

Question 4

This protein usually exposes a site on factor V to which protein C can bind to and inactive the factor. Without this, decreased inactivation and increased coagulation

Answer 4

Protein S deficiency

Question 5

• Results from deficient B12 which is needed to convert homocystein to methione
• High homocystein levels make one more prone to endothelial cell injury–>inflammation–>clot formation

Answer 5

Homocysteinemia