Hyperlipidemias

Question 1

What is Type 1 hyperlipidemia and whaat does the plasma look like?

Answer 1

Familial hyperchylomicroemia-increase chylomicrons and TG, creamy top layer

Question 2

What is Type 1 caused by?

Answer 2

apoCII or lipoprotein lipase deficiencies

Question 3

What are Type 1s symptoms?

Answer 3

jaundice and xanthomas

Question 4

What will your blood work look like with type 1 hyperlipidemia?

Answer 4

Low LDL and increased chymomicrons

Question 5

What is Type 2 hyperlipidemia and what will the plasma look like?

Answer 5

Familial Hypercholesterolemia-increased LDL and increased Cholesterol-clear

Question 6

What will blood work look like for Type 2?

Answer 6

Increased LDL-rest normal

Question 7

What is Type 3 hyperlipidemia and what will the plasma look like?

Answer 7

Familial dysbetalipoproteinemia-increased TG and IDL and turbid

Question 8

What will blood work show for Type 3?

Answer 8

Broad VLDL/LDL band

Question 9

What causes a Type 3?

Answer 9

ApoE2 has reduced affinity for chylomicron due to structural change-remnants and cannot go to liver for degradation

Question 10

What are the results of Type 3 and treatments?

Answer 10

statins, resins, PCSK9 inhibitors, atherosclerosis

Question 11

What is type 4 hyperlipidemia and what does the plasma look like?

Answer 11

Familial hypertriglyceridemia-increased VLDL production by liver-turbid

Question 12

What does Type 4 look like on a blood test?

Answer 12

Increased VLDL