Hypersensitivity

Question 1

What is T1 hypersensitivity

Answer 1

IgE Mediated

-IgE binds to mast cell/basophil = degranulation = Histamine release

Question 2

What does histamine release cause

Answer 2

Vasoconstriction
Increased permeability @H1
Bronchoconstriction

Question 3

What is the difference between T2 and T3 hypersensitivity

Answer 3

Antigen Antibody complement activated complement
T2= At site of binding
T3= Away from site (Deposition)

Question 4

What HS is T cell mediated

Answer 4

T4

-Activated TH1 by APC

Question 5

What is Anaphylaxis

Answer 5

T1 IgE mediated Hypersensitivity Emergency

Question 6

How does anaphylaxis present

Answer 6

Shock (Hypotension, Tachycardia, Dyspnoea, Cold, Pale w/ Puffy face)

Question 7

How is Anaphylaxis managed

Answer 7

ABCDE
500 mg IM Adrenaline
Antiistamines
Cortisol