Hypersensitivity

Question 1

Type 1 Hypersensitivity occurs after ____, when immune system develops ____. Ag-specific ___ bound to ____ on ____. Receptor __ releases __.

Answer 1

Initial exposure, IgE, FceRI, mast/baso/eos

Crosslinking, Histamine and TNF-alpha

Question 2

Type 4 Hypersensitivity

Answer 2

T-cell based
Delayed Type (TB)
Contact (haptens, metal ions)
Gluten-sensitive enteropathy (gliadin)

Question 3

IgE-mediated allergy

Answer 3

Systemic anaphylaxis
Wheal and flare (local)
Allergic rhinitis (hay fever)
Bronchial asthma
Food allergy

Question 4

Two types of mast cells

Answer 4

Connective tissue

Skin (mostly IgE)