Hypersensitivity Responses

Question 1

Type I

Answer 1

• IgE dependent (antibody in serum)
	• Cytokine IL-4 Produced 
	• B-cell response 
	• B-cells produce more IgE
Mediators and cytokines are released

Question 2

Type II

Answer 2

• Self-reactive T-cells are released
• Produce IgE and IgM
Mediate cell death

Question 3

Type III

Answer 3

• Antibody mediated
• Form immune complexes in the blood
• Neutrophils are recruited
Degranulation

Question 4

Type IV

Answer 4

• T-cell mediated
• Cytokines produced by activated macrophages
Inflammatory responses
requires gamma interferon production

Question 5

Type V

Answer 5

• Antibody mediated dysfunction

Similar process to type II except function is lost