Hypertrophy

Question 1

Concentric Hypertrophy

Answer 1

• Concentric thickening of the ventricular wall

Question 2

Cause for concentric hypertrophy

Answer 2

• Increased mechanical load

- May be in surviving CMs after MI

Question 3

Wall-thinning and dilatation

Answer 3

• Adverse remodelling
• Can result from concentric hypertrophy
• May be direct, due to valve disease and volume overload etc.

Question 4

Concentric HT and dilatation both show

Answer 4

• Myocyte enlargement
• Reprogrammed gene expression
• Fibrosis
• Contractile dysfunction

Question 5

Athletics and HT, difference with HF

Answer 5

• Pressure loading (weight-lifter)
• Volume loading (cyclist)
• Hearts may look similar but function will be different
• Adverse Ca handling (from reprogrammed gene expression) is unique to HF