when beta cells produce insulin, how is it released?
as proinsulin
what is proinsulin cleaved into?
insulin + C peptide
hypoglycemia activates what sort of response?
adrenergic response
autonomic sx of hypoglycemia
sweating, anxiety, tachycardia
most common cause of hypoglycemia in adults
diabetics who are on insulin tx
whipple triad?
islet cell tumor
hypoglycemia, relief of sx after restoration of normoglycemia
whipple triad
fasting glu
insulinoma
what drug can be used for dx of insulinoma?
tobutamide
MOA of tobutamide
drug promotes production and release of insulin
acute management of hypoglycemia if patient unconscious
glucagon IV or SQ