IBD

Question 1

Clinical features UC

Answer 1

• continuous inflammation
• Colon Only
• superficial

Question 2

Clinical features Crohns Disease

Answer 2

• Patchy inflammation
• total GI involvement
• full-thickness inflammation
• formation of fistulas/strictures

Question 3

UC Gross Morphology

Answer 3

• Absence of mucosal vascular pattern
• granular mucosa w/ pinpoint hemorrhages
• Mucopus ulcerations

Question 4

UC Histo

Answer 4

• N/0 invasion into epithelium of crypts forming Abcesses

- Necrosis + eventual Toxic megacolon

Question 5

UC LabDc

Answer 5

• INC ESR + CRP
• Fe-deficient Anemia
• DEC Albumin
• Elevated LFTs

Question 6

Crohns Gross appearance

Answer 6

• Apthous or linear ulcers

- Cobblestone mucosa w/ transmural inflammation

Question 7

Crohns LabDx

Answer 7

• INC ESR.CRP
• Fe deficiency
• Folate + B12 deficiency
• DEC Total protein
• Non-caseating granuloma on microscope

Question 8

UC/Crohns Tx

Answer 8

• Aminosalicylates (5-ANA)
• Abx
• steroids
• Immunomodulators (Anti-TNF)

Question 9

Anti-TNF Agents

Answer 9

• Infliximab
• Adalimumab
• Certolizumab

Question 10

Anti-adherence Integrins Agents

Answer 10

Natalizumab

Vedolizumab

Question 11

Natalizumab AE

Answer 11

Progressive multifocal leukoencephalopathy