ICU

Question 1

Adrenaline MOA

Answer 1

β>α
β1 = +HR, +inotropy, +CO α at higher doses preserves coronary & cerebral blood flow
β2 = +vasodilate, +bronchodilate

Question 2

Noradrenaline MOA

Answer 2

α>β

α1 = +SVR, +β at higher doses

Question 3

Dopamine MOA

Answer 3

DA > β > α
Dose dependent
1-5 = DAR 1+2 
5-10 = betaR 
>10 = αR +aldosterone

Question 4

Dobutamine MOA

Answer 4

β1 and 2
Inotropy
\+VO2
\+ myocardial work, mild +HR, +coronary perfusion
Mild -SVR, mild -PVR

Question 5

Vasopressin MOA

Answer 5

Antidiuresis +SVR +platelet aggregation +PVR -splanchnic flow

Question 6

Levosimendan MOA

Answer 6

Calcium sensitizer

inotrope and vasodilator

Question 7

Milrinone

Answer 7

cAMP PDE-3 inhibitor

Inotropy -SVR -PVR +CO

Question 8

Isoprenaline

Answer 8

non selective beta agonist and predominantly chronotropic