IgM-Specific Serology

Question 1

Describe the structure of an IgM antibody

Answer 1

Pentameric structure with J - chain the the middle (be able to draw and label)

Question 2

When is IgM produced in an infection?

Answer 2

it is the first antibody produced

Question 3

What are 2 advantages of IgM -specific testing in acquired infections?

Answer 3

1. would not have to wait 2-3 weeks to compare IgG levels in acute and convalescent samples
2. faster results; testing of only a single sample

Question 4

What are 2 advantages of IgM- specific testing in congenital infections

Answer 4

1. would not have to worry about detecting maternal antibodies
2. faster results; testing only a single sample instead of sequential samples during baby’s first 6 months of life