Discuss in the context of simple receptor theory, concept of affinity and the significance of the dissociation equilibrium constant
Discuss the difference between receptor occupancy and receptor activation and how this relates to the basic principles of the ‘two-state’ model
Discuss the properties of full, partial and inverse agonists
Discuss the concepts of potency and efficacy
Discuss the concept of biased agonism
Discuss the concept of ‘spare receptors’ and how it can relate to non-competitive antagonism.
Discuss, with selected examples, the properties of competitive, non-competitive, reversible and irreversible antagonists.
Discuss the concept of constitutively active receptors and how inverse agonists act at these receptors.
Discuss, with selected examples, the mechanisms that allow drugs to cross cell barriers.
Discuss, with selected examples, how the particular physiochemical properties of drugs favour particular routes across cell barriers.
Discuss how the apparent volume of distribution can be used to both predict physiochemical properties of a drug, predict drug plasma concentration as a function of determined doses and be used to arrive at a dose that will give a desired plasma concentration.
Discuss how plasma protein binding and tissue protein binding can determine the volume of distribution.
Discuss the advantages and disadvantages of the different routes of drug administration
Discuss the main pathways of drug metabolism, in regards to both Phase I and Phase II drug metabolism
Discuss the concept of bioavailability and how the bioavailability for a drug may be affected by the chosen route of administration
