IMHA

Question 1

What is primary hemostasis

Answer 1

Platelets (number and function) and formation of a platelet plug

Question 2

What is secondary hemostasis?

Answer 2

Formation of a fibrin mesh that stabilizes the platelet plug

Question 3

What sets off primary hemostasis?

Answer 3

Damage to the endothelium of a blood vessel

• vWF and GP1 released from collagen causing platelets to adhere
• Platelets stimulated to release ADP, TxA1, vWF

Question 4

T/F: Platelet activation recruits more platelets

Answer 4

True

Question 5

What defects in primary hemostasis can occur?

Answer 5

• Decreased platelets/thrombocytopenia
• Poorly functional platelets
• Lack of vWF (platelet and collagen derived)

Question 6

What defects in secondary hemostasis can occur?

Answer 6

Lack of or defects in any of the cogulation factors

Question 7

What are the clinical signs of primary hemostatic defects?

Answer 7

• Petechia
• Ecchymosis
• Oozing from mucosal sites

Question 8

What are the clinical signs of secondary hemostatic defects?

Answer 8

• Bleeding into a body cavity

- Large SQ hematomas

Question 9

T/F: Severe primary and secondary coagulopathies often have the same or similar clinical presentations.

Answer 9

True