Normal changes
responses to influenza, parainfluenza, pneumococcus, and varicella vaccines are less effective
inflammation often presents atypically in older individuals (low-grade fever and minimal pain)
thymus mass decreases steadily
T-cell activity declines & more immature T-cells are present in the thymus
decline in cell-mediated immunity
T lymphocytes are less able to proliferate in response to mitogens
Serum immunoglobulin (antibodies) concentration is not significantly altered
Low-grade fever
temperature is slightly elevated between 37.5°C and 38.3°C and lasts for more than 24 hours. Among the geriatric population
Immunosenescence
aging of the immune system
depressed immune response