Basophils and Mast cells whats the difference?
- basophils are in the circulation
- mast cells are in the tissues
What do basophils and mast cells function as?
inflammatory response
- release anticoagulant heparin
- release histamine
What does heparin do?
- anticoagulant
- slows blood clot
What does histamine do?
- vasodilation to increase blood flow (bring more immune cells)
What is the most abundant leukocyte?
neutrophils
What is included in the group of granulocytes?
- basophils, mast cells
- eosinophils
- neutrophils
What is the function of the neutrophil?
- immunity
- phagocytotic and ingest and kill bacteria
Which granulocyte is characterized as the first responders?
- neutrophils
Which granulocyte has a super power! What is it?
- neutrophils - extravasation
What is extravasation?
ability to squeeze between blood vessels and exit blood into the tissue
- this occurs when it receives a signal on the vessel wall
- mature neutrophil rolls - surveys, captures, adhesion and activation, spread, extravasation
- in tissue = phagocytosis bacteria
What is the role of eosinophils?
- a type of granulocyte
- releases substances from granulocyte
- kill parasite
(remember this is not a bacteria/virus)
Monocytes are in the bloodstream as ____ are in the tissues?
macrophages
What is the reticuloendothelial system? and mononuclear phagocyte system
another word for macrophage
What are 4 types of cells to the reticuloendothelial system?
4 types of macrophages (tissues)
- histocytes skin
- kupfer cells liver
- microglia brain
- osteoclasts bone
- reticuloendothelial cells spleen
Compare macrophages and neutrophils?
- macrophages are bigger
- macrophages are more effective
- remove old debris (RBC and neutrophils)
