Immune Cells

Question 1

NK cells activity enhanced by?

Answer 1

• IL-12 and IL 2
• IFN alpha and INF beta

Question 2

TH1 cell

• Secretes?
• Function?
• Induced by?
• Inhibited by?

Answer 2

• Secretes
  
  • INF gamma
• Function
  
  • activates macrophages and cytotoxic T cells to kill phagocytosed microbes
• Induced by
  
  • INF gamma
  • IL-12
• Inhibited by:
  
  • IL-4
  • IL-10 (from Th2 cell)

Question 3

Th2 cell

• Secretes
• Function
• Induced by
• Inhibited by

Answer 3

• Secretes
  
  • IL-4, IL-5, IL-6, IL-10, IL-13
• Function:
  
  • activate eosinophils and promote production of IgE for parasite defense
• Induced by
  
  • IL-2, IL-4
• Inhibited by:
  
  • INF-gamma (from Th1 cell)

Question 4

Th17 cell

• Secretes
• Function
• Induced by
• Inhibited by

Answer 4

• Secretes
  
  • IL-17, IL-21, IL-22
• Function
  
  • Immunity against extracellular microbes, through induction of neutrophilic inflammation
• Induced by
  
  • TGF- beta
  • IL-1, IL-6
• Inhibited by
  
  • IFN gamma
  • IL-4

Question 5

Treg

• Secretes
• Function
• Induced by
• Inhibited by

Answer 5

• Secretes
  
  • TGF-beta
  • IL-10, IL-35
• Function
  
  • Prevent autoimmunity by maintaining tolerance to self-antigens
• Induced by
  
  • TGF-beta
  • IL-2
• Inhibited by:
  
  • IL-6