Immuno

Question 1

What are the 2 genetic diseases associated with immunodeficiency in foals ?

Answer 1

• Severe combined immunodeficiency (SCID) in Arabian foals : failure to produce functional B and T lymphocytes → no adaptive immune response
• Foal immunodeficiency syndrome in young Fell and Dales pony foals : anemia, immunodeficiency, peripheral ganglionopathy

Question 2

What are the primary immunodeficiencies in horses ? (4)

Answer 2

• Severe combined immunodeficiency (SCID) : in Arabian foals, failure to produce functional B- and T-lymphocytes → absolute lymphopenia
• Foal immunodeficiency syndrome in Fell and Dales ponies → anemia, B-cell lymphopenia
• Common variable immunodeficiency (CVID) in adult horses → failure of B-cell development in bone marrow
• Selective IgM deficiency in Arabian and QH (foals an adults)