IMMUNO

Question 0

AIDS

Pres?

Answer 0

PRES:
- Ring-enhancing Brain lesions (caused by CNS Lymphoma or
Toxoplasma gondii)
- Kaposi Sarcoma + Bacillary Angiomatosis

Question 1

HIV

Pres?

Answer 1

PRES:

- Hairy Leukoplakia

Question 2

Hyper IgE / Job Sx

Def’n, Pres (2)?

Answer 2

Neutrophil Chemotaxis abnormality.

PRES:

• “Recurrent Colds”
• “Unusual Eczema”

Question 3

Chediak-Higashi Sx

Def’n, Micro Finding, Pres (general)?

Answer 3

Congenital failure of phagolysosome formation.

FINDING:
- LARGE LYSOSOMAL VESICLES in phagocytes

PRES = Immunodeficiency

Question 4

Goodpasture Sx

Def’n, Pres, Comp?

Answer 4

Anti-Basement Memb antibodies.

PRES: BLEEDING

• Lung bleeding
• Kidney bleeding

COMP:
- RPGN

Question 5

SCID

Causes?

Answer 5

CAUSES:

- Adenosine Deaminase def (a Purine Salvage def)

Question 6

Immunocompromise

Seen In (4)?

Answer 6

SEEN IN:

• Neonates
• HIV/AIDS
• Diabetes
• Steroid users

Question 7

Serum Sickness

Mech (4 steps), Causes, Pres (5)?

Answer 7

MECH: Type 3 HS.
Ab to foreign proteins produced (5 days after Ag exposure) ->
Ag-Ab IC form + deposit in MEMB ->
Ag-Ab IC fix complement -> Tis damage.

CAUSES: Drugs (MC) or Serum

PRES: 5-10 days after Ag exposure

• Arthralgias
• Fever
• Lymphadenopathy
• Proteinuria
• Urticaria

Question 8

Granulomatous Diseases- Examples

• Immuno?
• Gen Path?
• Micro (6):
  - Bacteria / Bacterial Groups (4)?
  - Fungal?
  - Parasitic?
• Heme (2)?
• GI?

Answer 8

• IMMUNO: Sarcoidosis
• GEN PATH: Berylliosis
• MICRO:
  - Bacterial:
  - Listeria monocytogenes (-> Gran Infantiseptica)
  - M leprae + tuberculosis
  - Zoonotic: Bartonella + Francisella
  - Treponema pallidum
  - Fungal: Blastomycosis, Histoplasmosis
  - Parasitic: Schistosomiasis
• HEME:
  - Churg-Strauss Sx
  - Granulomatosis w Polyangitis (Wegener)
• GI: Crohn Dz